Synthesis of novel C-9 carbon substituted derivatives of artemisinin

Synthesis of novel C-9 carbon substituted derivatives of artemisinin

Several artemisinin derivatives carrying several groups (alkyl, hydroxyalkyl, allyl or azide) at position 9 have been synthesized starting from artemisinin via enolate formation and subsequent reaction with appropriate electrophiles. [Display omitted] Several artemisinin derivatives carrying several...

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Veröffentlicht in:Bioorganic & medicinal chemistry 2017-11, Vol.25 (22), p.6098-6101
Hauptverfasser: Meyer, Daniel, Smeilus, Toni, Pliatsika, Dimanthi, Mousavizadeh, Farnoush, Giannis, Athanassios
Format: Artikel
Sprache:eng
Schlagworte:
Aldehydes - chemistry
Anticancer
Antimalarial
Antimalarials - chemical synthesis
Antimalarials - chemistry
Antimalarials - pharmacology
Artemisinin
Artemisinins - chemical synthesis
Artemisinins - chemistry
Artemisinins - pharmacology
Carbon - chemistry
Plasmodium falciparum - drug effects
Stereoisomerism
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Zusammenfassung:Several artemisinin derivatives carrying several groups (alkyl, hydroxyalkyl, allyl or azide) at position 9 have been synthesized starting from artemisinin via enolate formation and subsequent reaction with appropriate electrophiles. [Display omitted] Several artemisinin derivatives carrying several groups (alkyl, hydroxyalkyl, allyl or azide) at position 9 have been synthesized starting from artemisinin via enolate formation and subsequent reaction with appropriate electrophiles.
ISSN:0968-0896
1464-3391
DOI:10.1016/j.bmc.2017.03.021