Apigenin-7-diglucuronide protects retinas against bright light-induced photoreceptor degeneration through the inhibition of retinal oxidative stress and inflammation

Highlights • A7DG protected photoreceptors from light-induced degeneration in mice. • A7DG suppressed photo-oxidative stress in mouse retinas. • A7DG attenuated light-induced retinal gliosis and microglial activation. • A7DG decreased the expression of proinflammatory genes in light-exposed retinas....

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Veröffentlicht in:	Brain research 2017-05, Vol.1663, p.141-150
Hauptverfasser:	Bian, Minjuan, Zhang, Yong, Du, Xiaoye, Xu, Jing, Cui, Jingang, Gu, Jiangping, Zhu, Weiliang, Zhang, Teng, Chen, Yu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apigenin - metabolism Apigenin - pharmacology Apigenin - therapeutic use Apigenin-7-diglucuronide Apoptosis - drug effects Electroretinography - drug effects Inflammation - pathology Light - adverse effects Macular Degeneration - drug therapy Mice Mice, Inbred BALB C Neurology Oxidative stress Oxidative Stress - drug effects Oxidative Stress - physiology Photoreceptor Cells - metabolism Photoreceptor Cells, Vertebrate - drug effects Photoreceptor Cells, Vertebrate - physiology Photoreceptor degeneration Protective Agents - pharmacology Radiation Injuries, Experimental - pathology Retina - drug effects Retina - metabolism Retinal Degeneration - pathology Retinal inflammation
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Zusammenfassung:	Highlights • A7DG protected photoreceptors from light-induced degeneration in mice. • A7DG suppressed photo-oxidative stress in mouse retinas. • A7DG attenuated light-induced retinal gliosis and microglial activation. • A7DG decreased the expression of proinflammatory genes in light-exposed retinas. • A7DG is a promising agent for treating photoreceptor degenerative disorders.
ISSN:	0006-8993 1872-6240
DOI:	10.1016/j.brainres.2017.03.019