Spanish version of the Mattis Dementia Rating Scale‐2 for early detection of Alzheimer's disease and mild cognitive impairment

Objective We aimed to analyse the clinical utility of the Mattis Dementia Rating Scale (MDRS‐2) for early detection of Alzheimer's disease (AD) and amnestic mild cognitive impairment (MCI) in a sample of Spanish older adults. Methods A total of 125 participants (age = 75.12 ± 6.83, years of education =7.08 ± 3.57) were classified in three diagnostic groups: 45 patients with mild AD, 37 with amnestic MCI—single and multiple domain and 43 cognitively healthy controls (HCs). Reliability, criterion validity and diagnostic accuracy of the MDRS‐2 (total and subscales) were analysed. The MDRS‐2 scores, adjusted by socio‐demographic characteristics, were calculated through hierarchical multiple regression analysis. Results The global scale had adequate reliability (α = 0.736) and good criterion validity (r = 0.760, p