A novel mode of RBD-protein recognition in the Y14-Mago complex

Y14 and Mago are conserved eukaryotic proteins that associate with spliced mRNAs in the nucleus and remain associated at exon junctions during and after nuclear export. In the cytoplasm, Y14 is involved in mRNA quality control via the nonsense-mediated mRNA decay (NMD) pathway and, together with Mag...

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Veröffentlicht in:	Nature structural & molecular biology 2003-06, Vol.10 (6), p.433-439
Hauptverfasser:	Conti, Elena, Fribourg, Sébastien, Gatfield, David, Izaurralde, Elisa
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Binding Sites Biochemistry Biological Microscopy Biomedical and Life Sciences Cells, Cultured Conserved Sequence Crystallography, X-Ray Dimerization Drosophila Proteins - chemistry Drosophila Proteins - genetics Drosophila Proteins - metabolism Humans Life Sciences Macromolecular Substances Membrane Biology Models, Molecular Molecular Sequence Data Mutagenesis, Site-Directed Nuclear Proteins - chemistry Nuclear Proteins - genetics Nuclear Proteins - metabolism Protein Binding Protein Structure Protein Structure, Tertiary - physiology Quality control RNA, Messenger - metabolism RNA-Binding Proteins - chemistry RNA-Binding Proteins - genetics RNA-Binding Proteins - metabolism Sequence Homology, Amino Acid Substrate Specificity
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