Plasma proANP1–98 levels are positively associated with central obesity: A cross-sectional study in a general population of China
Atrial natriuretic peptide (ANP) and its prohormone activating enzyme are associated with central obesity, suggesting there may be a potential relationship between proANP1–98 and central obesity. However, the association is still lack of population-based evidence. We explored the association in a ge...
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| Veröffentlicht in: | Clinica chimica acta 2017-06, Vol.469, p.26-30 |
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| container_title | Clinica chimica acta |
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| creator | Zhu, Zhengbao Zhang, Qiu Peng, Hao Zhong, Chongke Liu, Yan Huangfu, Xinfeng Tian, Yunfan Chao, Xiangqin Wang, Aili Jin, Jianhua Zhang, Yonghong |
| description | Atrial natriuretic peptide (ANP) and its prohormone activating enzyme are associated with central obesity, suggesting there may be a potential relationship between proANP1–98 and central obesity. However, the association is still lack of population-based evidence. We explored the association in a general population of China.
We measured plasma proANP1–98, waist circumference and other traditional biomarkers in 2203 participants aged≥30y. Multivariate logistic regression models were used to determine the association between plasma proANP1–98 and central obesity, and odds ratio (OR) and 95% confidence interval (CI) were calculated.
High proANP1–98 was significantly associated with increased risk of central obesity in participants, and the multivariate adjusted OR (95% CI) of central obesity associated with the second, third and fourth quartiles of proANP1–98 were 1.33 (1.03–1.72), 1.69 (1.31–2.19) and 1.76 (1.35–2.29), respectively, compared with the lowest quartile of proANP1–98. There was a dose-response relationship between proANP1–98 and risk of central obesity among the participants (Ptrend |
| doi_str_mv | 10.1016/j.cca.2017.03.019 |
| format | Article |
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We measured plasma proANP1–98, waist circumference and other traditional biomarkers in 2203 participants aged≥30y. Multivariate logistic regression models were used to determine the association between plasma proANP1–98 and central obesity, and odds ratio (OR) and 95% confidence interval (CI) were calculated.
High proANP1–98 was significantly associated with increased risk of central obesity in participants, and the multivariate adjusted OR (95% CI) of central obesity associated with the second, third and fourth quartiles of proANP1–98 were 1.33 (1.03–1.72), 1.69 (1.31–2.19) and 1.76 (1.35–2.29), respectively, compared with the lowest quartile of proANP1–98. There was a dose-response relationship between proANP1–98 and risk of central obesity among the participants (Ptrend<0.001). Sensitivity analyses further confirmed these associations. Adding proANP1–98 to a model containing conventional risk factors improved discriminatory power of central obesity (as shown by significant improvement in continuous NRI and IDI).
Contrary to known reduced ANP levels in central obesity, we found that plasma proANP1–98 was positively associated with central obesity, suggesting that elevated plasma proANP1–98 may be a marker or a risk factor for central obesity.
•We first studied the association of plasma proANP1–98 with central obesity in a general population.•We found that plasma proANP1–98 was significantly and positively associated with central obesity.•Elevated plasma proANP1–98 may be a marker or a risk factor for central obesity.</description><identifier>ISSN: 0009-8981</identifier><identifier>EISSN: 1873-3492</identifier><identifier>DOI: 10.1016/j.cca.2017.03.019</identifier><language>eng</language><publisher>Elsevier B.V</publisher><subject>Central obesity ; Chinese ; Cross-sectional study ; Plasma proANP ; Waist circumference</subject><ispartof>Clinica chimica acta, 2017-06, Vol.469, p.26-30</ispartof><rights>2017</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.cca.2017.03.019$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids></links><search><creatorcontrib>Zhu, Zhengbao</creatorcontrib><creatorcontrib>Zhang, Qiu</creatorcontrib><creatorcontrib>Peng, Hao</creatorcontrib><creatorcontrib>Zhong, Chongke</creatorcontrib><creatorcontrib>Liu, Yan</creatorcontrib><creatorcontrib>Huangfu, Xinfeng</creatorcontrib><creatorcontrib>Tian, Yunfan</creatorcontrib><creatorcontrib>Chao, Xiangqin</creatorcontrib><creatorcontrib>Wang, Aili</creatorcontrib><creatorcontrib>Jin, Jianhua</creatorcontrib><creatorcontrib>Zhang, Yonghong</creatorcontrib><title>Plasma proANP1–98 levels are positively associated with central obesity: A cross-sectional study in a general population of China</title><title>Clinica chimica acta</title><description>Atrial natriuretic peptide (ANP) and its prohormone activating enzyme are associated with central obesity, suggesting there may be a potential relationship between proANP1–98 and central obesity. However, the association is still lack of population-based evidence. We explored the association in a general population of China.
We measured plasma proANP1–98, waist circumference and other traditional biomarkers in 2203 participants aged≥30y. Multivariate logistic regression models were used to determine the association between plasma proANP1–98 and central obesity, and odds ratio (OR) and 95% confidence interval (CI) were calculated.
High proANP1–98 was significantly associated with increased risk of central obesity in participants, and the multivariate adjusted OR (95% CI) of central obesity associated with the second, third and fourth quartiles of proANP1–98 were 1.33 (1.03–1.72), 1.69 (1.31–2.19) and 1.76 (1.35–2.29), respectively, compared with the lowest quartile of proANP1–98. There was a dose-response relationship between proANP1–98 and risk of central obesity among the participants (Ptrend<0.001). Sensitivity analyses further confirmed these associations. Adding proANP1–98 to a model containing conventional risk factors improved discriminatory power of central obesity (as shown by significant improvement in continuous NRI and IDI).
Contrary to known reduced ANP levels in central obesity, we found that plasma proANP1–98 was positively associated with central obesity, suggesting that elevated plasma proANP1–98 may be a marker or a risk factor for central obesity.
•We first studied the association of plasma proANP1–98 with central obesity in a general population.•We found that plasma proANP1–98 was significantly and positively associated with central obesity.•Elevated plasma proANP1–98 may be a marker or a risk factor for central obesity.</description><subject>Central obesity</subject><subject>Chinese</subject><subject>Cross-sectional study</subject><subject>Plasma proANP</subject><subject>Waist circumference</subject><issn>0009-8981</issn><issn>1873-3492</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNotkM1KAzEUhYMoWKsP4C5LNzPmZ6ZJdFWKf1C0C12HNHNjU6aTcTKtdCf4CL6hT2KGuroczseF8yF0SUlOCZ1cr3NrTc4IFTnhOaHqCI2oFDzjhWLHaEQIUZlUkp6isxjXKRZkQkfoe1GbuDG47cL0eUF_v36UxDXsoI7YdIDbEH3vU9xjE2Ow3vRQ4U_fr7CFpu9MjcMSErO_wVNsuxBjFsH2PjSpiv222mPfYIPfoYGBbkO7rc3Q4-DwbOUbc45OnKkjXPzfMXq7v3udPWbzl4en2XSeAS3LPjOgmJMSJo5LUwjpilIooRwXTJSGF9ZRx6pCSmsVV6wwllVLWyrh-BJK6vgYXR3-prEfW4i93vhooa5NA2EbNZWSEMlZyRJ6e0CTB9h56HS0HhoLle_SOl0FrynRg3q91km9HtRrwnVSz_8AY8R7Lw</recordid><startdate>201706</startdate><enddate>201706</enddate><creator>Zhu, Zhengbao</creator><creator>Zhang, Qiu</creator><creator>Peng, Hao</creator><creator>Zhong, Chongke</creator><creator>Liu, Yan</creator><creator>Huangfu, Xinfeng</creator><creator>Tian, Yunfan</creator><creator>Chao, Xiangqin</creator><creator>Wang, Aili</creator><creator>Jin, Jianhua</creator><creator>Zhang, Yonghong</creator><general>Elsevier B.V</general><scope>7X8</scope></search><sort><creationdate>201706</creationdate><title>Plasma proANP1–98 levels are positively associated with central obesity: A cross-sectional study in a general population of China</title><author>Zhu, Zhengbao ; Zhang, Qiu ; Peng, Hao ; Zhong, Chongke ; Liu, Yan ; Huangfu, Xinfeng ; Tian, Yunfan ; Chao, Xiangqin ; Wang, Aili ; Jin, Jianhua ; Zhang, Yonghong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-e155t-ae92f88e6f38a478f457979f37275a34cf1f2d488cc93924ac2dbc597f3be51f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Central obesity</topic><topic>Chinese</topic><topic>Cross-sectional study</topic><topic>Plasma proANP</topic><topic>Waist circumference</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhu, Zhengbao</creatorcontrib><creatorcontrib>Zhang, Qiu</creatorcontrib><creatorcontrib>Peng, Hao</creatorcontrib><creatorcontrib>Zhong, Chongke</creatorcontrib><creatorcontrib>Liu, Yan</creatorcontrib><creatorcontrib>Huangfu, Xinfeng</creatorcontrib><creatorcontrib>Tian, Yunfan</creatorcontrib><creatorcontrib>Chao, Xiangqin</creatorcontrib><creatorcontrib>Wang, Aili</creatorcontrib><creatorcontrib>Jin, Jianhua</creatorcontrib><creatorcontrib>Zhang, Yonghong</creatorcontrib><collection>MEDLINE - Academic</collection><jtitle>Clinica chimica acta</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhu, Zhengbao</au><au>Zhang, Qiu</au><au>Peng, Hao</au><au>Zhong, Chongke</au><au>Liu, Yan</au><au>Huangfu, Xinfeng</au><au>Tian, Yunfan</au><au>Chao, Xiangqin</au><au>Wang, Aili</au><au>Jin, Jianhua</au><au>Zhang, Yonghong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Plasma proANP1–98 levels are positively associated with central obesity: A cross-sectional study in a general population of China</atitle><jtitle>Clinica chimica acta</jtitle><date>2017-06</date><risdate>2017</risdate><volume>469</volume><spage>26</spage><epage>30</epage><pages>26-30</pages><issn>0009-8981</issn><eissn>1873-3492</eissn><abstract>Atrial natriuretic peptide (ANP) and its prohormone activating enzyme are associated with central obesity, suggesting there may be a potential relationship between proANP1–98 and central obesity. However, the association is still lack of population-based evidence. We explored the association in a general population of China.
We measured plasma proANP1–98, waist circumference and other traditional biomarkers in 2203 participants aged≥30y. Multivariate logistic regression models were used to determine the association between plasma proANP1–98 and central obesity, and odds ratio (OR) and 95% confidence interval (CI) were calculated.
High proANP1–98 was significantly associated with increased risk of central obesity in participants, and the multivariate adjusted OR (95% CI) of central obesity associated with the second, third and fourth quartiles of proANP1–98 were 1.33 (1.03–1.72), 1.69 (1.31–2.19) and 1.76 (1.35–2.29), respectively, compared with the lowest quartile of proANP1–98. There was a dose-response relationship between proANP1–98 and risk of central obesity among the participants (Ptrend<0.001). Sensitivity analyses further confirmed these associations. Adding proANP1–98 to a model containing conventional risk factors improved discriminatory power of central obesity (as shown by significant improvement in continuous NRI and IDI).
Contrary to known reduced ANP levels in central obesity, we found that plasma proANP1–98 was positively associated with central obesity, suggesting that elevated plasma proANP1–98 may be a marker or a risk factor for central obesity.
•We first studied the association of plasma proANP1–98 with central obesity in a general population.•We found that plasma proANP1–98 was significantly and positively associated with central obesity.•Elevated plasma proANP1–98 may be a marker or a risk factor for central obesity.</abstract><pub>Elsevier B.V</pub><doi>10.1016/j.cca.2017.03.019</doi><tpages>5</tpages></addata></record> |
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| subjects | Central obesity Chinese Cross-sectional study Plasma proANP Waist circumference |
| title | Plasma proANP1–98 levels are positively associated with central obesity: A cross-sectional study in a general population of China |
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