Plasma proANP1–98 levels are positively associated with central obesity: A cross-sectional study in a general population of China

Atrial natriuretic peptide (ANP) and its prohormone activating enzyme are associated with central obesity, suggesting there may be a potential relationship between proANP1–98 and central obesity. However, the association is still lack of population-based evidence. We explored the association in a general population of China. We measured plasma proANP1–98, waist circumference and other traditional biomarkers in 2203 participants aged≥30y. Multivariate logistic regression models were used to determine the association between plasma proANP1–98 and central obesity, and odds ratio (OR) and 95% confidence interval (CI) were calculated. High proANP1–98 was significantly associated with increased risk of central obesity in participants, and the multivariate adjusted OR (95% CI) of central obesity associated with the second, third and fourth quartiles of proANP1–98 were 1.33 (1.03–1.72), 1.69 (1.31–2.19) and 1.76 (1.35–2.29), respectively, compared with the lowest quartile of proANP1–98. There was a dose-response relationship between proANP1–98 and risk of central obesity among the participants (Ptrend