Tumor-cell targeting polydiacetylene micelles encapsulated with an antitumor drug for the treatment of ovarian cancer

Tumor-cell targeting polydiacetylene micelles encapsulated with an antitumor drug for the treatment of ovarian cancer

Peptide functionalized polydiacetylene (PDA) micelles encapsulated with camptothecin (CPT) kill ovarian cancer cells by the lysosome release of anticancer drug CPT. Moreover, the sub-30 nm PDA micelles penetrate efficiently into a tumor for enhanced therapeutic efficacy.

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Bibliographische Detailangaben
Veröffentlicht in:Chemical communications (Cambridge, England) England), 2017, Vol.53 (7), p.1233-1236
Hauptverfasser: Yao, Defan, Li, Shang, Zhu, Xiaomin, Wu, Junchen, Tian, He
Format: Artikel
Sprache:eng
Schlagworte:
Cancer
Drugs
Effectiveness
Encapsulation
Lysosomes
Micelles
PDA
Polydiacetylenes
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Beschreibung
Zusammenfassung:Peptide functionalized polydiacetylene (PDA) micelles encapsulated with camptothecin (CPT) kill ovarian cancer cells by the lysosome release of anticancer drug CPT. Moreover, the sub-30 nm PDA micelles penetrate efficiently into a tumor for enhanced therapeutic efficacy.
ISSN:1359-7345
1364-548X
DOI:10.1039/c6cc08581d