Cancer-Cell-Biomimetic Nanoparticles for Targeted Therapy of Homotypic Tumors

A unique biomimetic drug‐delivery system composed of 4T1‐breast‐cancer‐cell membranes and paclitaxel‐loaded polymeric nanoparticles (PPNs) (cell‐membrane‐coated PPNs), demonstrates superior interactions to its source tumor cells and elongated blood circulation, and displays highly cell‐specific targeting of the homotypic primary tumor and metastases, with successful inhibition of the growth and lung metastasis of the breast cancer cells.