Self-assembled Pt2L2 boxes strongly bind G-quadruplex DNA and influence gene expression in cancer cells

Self-assembled Pt2L2 boxes strongly bind G-quadruplex DNA and influence gene expression in cancer cells

Supramolecular Pt(ii) quadrangular boxes bind native and G-quadruplex DNA motifs in a size-dependent fashion. Three Pt molecular squares of distinct size show biological activity against cancer cells and heavily influence the expression of genes known to form G-quadruplexes in their promoter regions...

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Veröffentlicht in:Dalton transactions : an international journal of inorganic chemistry 2017, Vol.46 (2), p.329-332
Hauptverfasser: Domarco, O, Lotsch, D, Schreiber, J, Dinhof, C, Van Schoonhoven, S, Garcia, MD, Peinador, C, Keppler, B K, Berger, W, Terenzi, A
Format: Artikel
Sprache:eng
Schlagworte:
Biological activity
Boxes (containers)
Cancer
Deoxyribonucleic acid
Displays
Gene expression
Genes
Selectivity
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Zusammenfassung:Supramolecular Pt(ii) quadrangular boxes bind native and G-quadruplex DNA motifs in a size-dependent fashion. Three Pt molecular squares of distinct size show biological activity against cancer cells and heavily influence the expression of genes known to form G-quadruplexes in their promoter regions. The smallest Pt-box displays less activity but more selectivity for a quadruplex formed in the c-Kit gene.
ISSN:1477-9226
1477-9234
DOI:10.1039/c6dt03876j