In Vitro Gene Delivery with Large Porous Silicon Nanoparticles Fabricated Using Cost‐Effective, Metal‐Assisted Chemical Etching

In Vitro Gene Delivery with Large Porous Silicon Nanoparticles Fabricated Using Cost‐Effective, Metal‐Assisted Chemical Etching

The cytocompatibility, cell membrane affinity, and plasmid DNA delivery from surface oxidized, metal‐assisted stain‐etched mesoporous silicon nanoscale particles (pSiNPs) to human embryonic kidney (HEK293) cells is demonstrated, suggesting the possibility of using such material for targeted transfec...

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Veröffentlicht in:Small (Weinheim an der Bergstrasse, Germany) Germany), 2017-01, Vol.13 (3), p.np-n/a
Hauptverfasser: Wareing, Nancy, Szymanski, Kyle, Akkaraju, Giridhar R., Loni, Armando, Canham, Leigh T., Gonzalez‐Rodriguez, Roberto, Coffer, Jeffery L.
Format: Artikel
Sprache:eng
Schlagworte:
Affinity
Chemical etching
Cost-Benefit Analysis
Drug delivery systems
Etching
Fluorescein-5-isothiocyanate
gene delivery
Gene Transfer Techniques
Genes
HEK293 Cells
Humans
Kidneys
Metals - chemistry
Microscopy, Confocal
nanomedicine
Nanoparticles
Nanoparticles - chemistry
Nanostructure
Nanotechnology
Particle Size
Porosity
porous silicon
Silicon
Silicon - chemistry
Sonication
stain etching
surface modification
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Zusammenfassung:The cytocompatibility, cell membrane affinity, and plasmid DNA delivery from surface oxidized, metal‐assisted stain‐etched mesoporous silicon nanoscale particles (pSiNPs) to human embryonic kidney (HEK293) cells is demonstrated, suggesting the possibility of using such material for targeted transfection and drug delivery.
ISSN:1613-6810
1613-6829
DOI:10.1002/smll.201602739