Smooth Muscle Cell-Mimetic CO-Regulated Ion Nanochannels

Smooth Muscle Cell-Mimetic CO-Regulated Ion Nanochannels

A CO‐regulated ion nanochannel is demonstrated, which is inspired by the living activity of CO‐induced smooth muscle vasodilation. The mechanism relies on the fact that CO has a higher affinity with ferroporphyrin compared to carboxyl groups on the surface of the nanochannels. The cooperation effect...

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Veröffentlicht in:Advanced materials (Weinheim) 2016-12, Vol.28 (48), p.10780-10785
Hauptverfasser: Xu, Yanglei, Sui, Xin, Jiang, Jiaqiao, Zhai, Jin, Gao, Longcheng
Format: Artikel
Sprache:eng
Schlagworte:
Affinity
Asymmetry
carbon monoxide
Carboxyl group
Cooperation
ferroporphyrin
ion current rectification
ion nanochannels
K+ channels
K+ channels, ion nanochannels
Materials science
Muscles
Nanostructure
Smooth muscle
Surface chemistry
Transportation
Vasodilation
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Beschreibung
Zusammenfassung:A CO‐regulated ion nanochannel is demonstrated, which is inspired by the living activity of CO‐induced smooth muscle vasodilation. The mechanism relies on the fact that CO has a higher affinity with ferroporphyrin compared to carboxyl groups on the surface of the nanochannels. The cooperation effect of the released carboxyl groups and the conical asymmetric shape leads the ion transportation to be diode‐like.
ISSN:0935-9648
1521-4095
DOI:10.1002/adma.201603478