A hydrophilicity-based fluorescent strategy to differentiate cysteine/homocysteine over glutathione both in vivo and in vitro

A hydrophilicity-based fluorescent strategy to differentiate cysteine/homocysteine over glutathione both in vivo and in vitro

An easily-prepared probe/nanogel composite indicator HTBNM/PU was presented, which showed selective fluorescence responses to cysteine/homocysteine over glutathione both in vivo and in vitro based on the different hydrophilicity of these biothiols. In principle, this approach could endow any lipophi...

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Veröffentlicht in:RSC advances 2017, Vol.7 (10), p.5549-5553
Hauptverfasser: Peng, Xiaoman, Yuan, Hua, Xu, Jian, Lu, Fengxian, Wang, Liangqian, Guo, Xudong, Wang, Shuangqing, Li, Shayu, Li, Yi, Yang, Guoqiang
Format: Artikel
Sprache:eng
Schlagworte:
Amino acids
Cysteine
Fluorescence
Glutathione
In vitro testing
Indicators
Nanostructure
Strategy
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Zusammenfassung:An easily-prepared probe/nanogel composite indicator HTBNM/PU was presented, which showed selective fluorescence responses to cysteine/homocysteine over glutathione both in vivo and in vitro based on the different hydrophilicity of these biothiols. In principle, this approach could endow any lipophilic thiol indicator with selectivity for sulfur-containing amino acids.
ISSN:2046-2069
2046-2069
DOI:10.1039/C6RA27074C