Ebola Vaccination Using a DNA Vaccine Coated on PLGA‐PLL/γPGA Nanoparticles Administered Using a Microneedle Patch

Ebola DNA vaccine is incorporated into PLGA‐PLL/γPGA nanoparticles and administered to skin using a microneedle (MN) patch. The nanoparticle delivery system increases vaccine thermostability and immunogenicity compared to free vaccine. Vaccination by MN patch produces stronger immune responses than...

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Veröffentlicht in:	Advanced healthcare materials 2017-01, Vol.6 (1), p.np-n/a
Hauptverfasser:	Yang, Hung‐Wei, Ye, Ling, Guo, Xin Dong, Yang, Chinglai, Compans, Richard W., Prausnitz, Mark R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals cationic nanoparticles Coating Delivery systems Deoxyribonucleic acid Ebola DNA vaccine Ebola Vaccines - chemistry Ebola Vaccines - pharmacology Health care HeLa Cells Humans Immunogenicity, Vaccine indradermal vaccine delivery Lactic Acid - chemistry Lactic Acid - pharmacology Mice microneedle patch minimally invasive skin vaccination Nanoparticles Nanoparticles - chemistry Nanoparticles - therapeutic use Needles Polyglutamic Acid - chemistry Polyglutamic Acid - pharmacology Polyglycolic Acid - chemistry Polyglycolic Acid - pharmacology Polylysine - chemistry Polylysine - pharmacology Thermal stability Vaccines Vaccines, DNA - chemistry Vaccines, DNA - pharmacology
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Beschreibung
Zusammenfassung:	Ebola DNA vaccine is incorporated into PLGA‐PLL/γPGA nanoparticles and administered to skin using a microneedle (MN) patch. The nanoparticle delivery system increases vaccine thermostability and immunogenicity compared to free vaccine. Vaccination by MN patch produces stronger immune responses than intramuscular administration.
ISSN:	2192-2640 2192-2659
DOI:	10.1002/adhm.201600750