Quantitative Investigation of the Structural, Thermal, and Mechanical Properties of Polymorphs of a Fluorinated Amide

The discovery of three polymorphs of N‐(3,5‐difluorophenyl)‐2,4‐difluorobenzamide, of which two exist as concomitant polymorphs, highlights the significance of short, linear C−H⋅⋅⋅F intermolecular interactions in the solid state. The formation of these polymorphs can be regulated by monitoring the scan rate in differential scanning calorimetry. The phases have been characterized structurally and the investigation of the mechanical properties depicts that Form 1 is stiffer and harder than Form 2 by 50 % and 33 %, respectively. Three polymorphs of N‐(3,5‐difluorophenyl)‐2,4‐difluorobenzamide have been discovered with significant short, linear C−H⋅⋅⋅F intermolecular interactions in the solid state. The obtained phase is very sensitive to the differential scanning calorimetry scan rate. Nanomechanical characterization on both of the polymorphs reveals that Form 1 is stiffer and harder than Form 2, which correlates well with the underlying crystal packing.