Exploring the activity of a polyazine bridged Ru(ii)-Pt(ii) supramolecule in F98 rat malignant glioma cells

The mixed-metal supramolecular complex, [(Ph phen) Ru(dpp)PtCl ] , displays significant DNA modification, cell growth inhibition, and toxicity towards F98 malignant glioma cells following visible light irradiation. The design of this complex affords superior cellular uptake and antiproliferative act...

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Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2017, Vol.53 (1), p.145-148
Hauptverfasser:	Zhu, Jie, Rodríguez-Corrales, José Á, Prussin, Reece, Zhao, Zongmin, Dominijanni, Anthony, Hopkins, Samantha L, Winkel, Brenda S J, Robertson, John L, Brewer, Karen J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Antiproliferatives Cell Line, Tumor Cell Proliferation - drug effects Cell Proliferation - radiation effects Deoxyribonucleic acid Displays Glioma - pathology Inhibition Light Light irradiation Models, Molecular Molecular Conformation Organometallic Compounds - chemistry Organometallic Compounds - pharmacology Platinum - chemistry Polyazines Rats Ruthenium - chemistry Toxicity Uptakes
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Zusammenfassung:	The mixed-metal supramolecular complex, [(Ph phen) Ru(dpp)PtCl ] , displays significant DNA modification, cell growth inhibition, and toxicity towards F98 malignant glioma cells following visible light irradiation. The design of this complex affords superior cellular uptake and antiproliferative activity compared to the classic chemotherapeutic agent, cisplatin.
ISSN:	1359-7345 1364-548X
DOI:	10.1039/c6cc07978d