Self‐Assembling Brush Polymers Bearing Multisaccharides

Three different series of brush polymers bearing glucosyl, maltosyl, or maltotriosyl moiety at the bristle end are successfully prepared by using cationic ring‐opening polymerization and two sequential postmodification reactions. All brush polymers, except for the polymer containing 100 mol% maltotriosyl moiety, demonstrate the formation of multibilayer structure in films, always providing saccharide‐enriched surface. These self‐assembling features are remarkable, regarding the bulkiness of saccharide moieties and the kink in the bristle due to the triazole linker. The saccharide‐enriched film surfaces reveal exceptionally high specific binding affinity to concanavalin A but suppress nonspecific binding of plasma proteins severely. Overall, the brush polymers bearing saccharide moieties of various kinds in this study are highly suitable materials for biomedical applications including biosensors. Three different series of brush polymers bearing glucosyl, maltosyl, or maltotriosyl moiety at the bristle end are successfully prepared. Excitingly, they demonstrate the formation of multibilayer structure in films, always providing a saccharide‐enriched surface. The saccharide‐enriched film surfaces reveal exceptionally high specific binding affinity to concanavalin A but severely suppress nonspecific binding of plasma proteins.