Comparative assessment of intrinsic mechanical stimuli on knee cartilage and compressed agarose constructs

Highlights • Comparative assessment of intrinsic mechanical stimulus in cartilage and agarose. • Direct compression loading needs to be parameterized with time-dependence. • A multiple loading regime is advantageous relatively to a single loading regime. • Low compressive strain and low frequency increases principal strain stimulus. • High compressive strain and high frequency increases pore pressure stimulus.