Expanding the tetrahydroquinoline pharmacophore

[Display omitted] Tetrahydroquinoline is a privileged scaffold with a large number of biological applications. The tetrahydroquinoline pharmacophore has been expanded to yield 34 compounds. Biological screening of these compounds led to the identification of tetrahydroquinoline as neurotropic agents...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2017-04, Vol.27 (8), p.1714-1720
Hauptverfasser:	Goli, Navya, Mainkar, Prathama S., Kotapalli, Sudha Sravanti, K, Tejaswini, Ummanni, Ramesh, Chandrasekhar, Srivari
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Antitubercular Agents - chemical synthesis Antitubercular Agents - chemistry Antitubercular Agents - pharmacology Cattle Cell Line, Tumor Cycloaddition Reaction Drug Discovery Humans Mycobacterium bovis - drug effects Neurogenesis - drug effects Neurotropic agents Povarov reaction Quinolines - chemical synthesis Quinolines - chemistry Quinolines - pharmacology Small Molecule Libraries - chemical synthesis Small Molecule Libraries - chemistry Small Molecule Libraries - pharmacology Tetrahydroquinoline Tuberculosis, Bovine - drug therapy Tuberculosis, Bovine - microbiology
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Beschreibung
Zusammenfassung:	[Display omitted] Tetrahydroquinoline is a privileged scaffold with a large number of biological applications. The tetrahydroquinoline pharmacophore has been expanded to yield 34 compounds. Biological screening of these compounds led to the identification of tetrahydroquinoline as neurotropic agents not reported earlier.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/j.bmcl.2017.02.077