MiR-1, a potential predictive biomarker for recurrence in prostate cancer after radical prostatectomy

Abstract Background Increasing evidence is ithat aberrant miRNAs expressions are significantly associated with cancer progression. Previous studies have reported that the relative expression of miR-1 is significantly down-regulated in recurrent prostate cancer (PCa) samples when compared with non-recurrent PCa tissues. However, whether miR-1 can serve as a novel predicative biomarker for PCa recurrence still remains unclear. Methods The patients with clinically localized PCa who underwent radical prostatectomy by the same medical team at the Department of Urology, Ningbo NO.2 Hospital were enrolled in this study. We examined the miR-1 expression levels in recurrent and non-recurrent tumor samples by quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR). Univariate and multivariate Cox proportional hazard analyses were utilized for the evaluation of potential predictors of PCa recurrence. Results During the study period, 78 patients (including 27 in the recurrent group and 51 in the non-recurrent group) diagnosed with PCa and underwent radical prostatectomy were included in the final analysis. MiR-1 was significantly down-regulated in recurrent PCa tissues when compared to non-recurrent tumor samples (P