The Pten-Parkin Axis: At the Nexus of Cancer and Neurodegeneration

The Pten-Parkin Axis: At the Nexus of Cancer and Neurodegeneration

The PARK2 gene encodes an ubiquitin E3 ligase that is involved in mitochondrial homeostasis and linked to Parkinson’s disease. In this issue, Gupta et al. (2017) demonstrate that PARK2 expression is frequently reduced in human cancers and that this alteration leads to dysregulated PI3K signaling. Th...

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Veröffentlicht in:Molecular cell 2017-03, Vol.65 (6), p.959-960
Hauptverfasser: Ihle, Nathan T., Abraham, Robert T.
Format: Artikel
Sprache:eng
Schlagworte:
Humans
Mitochondria
Neoplasms
Parkinson Disease - genetics
Phosphatidylinositol 3-Kinases
Ubiquitin
Ubiquitin-Protein Ligases - genetics
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Zusammenfassung:The PARK2 gene encodes an ubiquitin E3 ligase that is involved in mitochondrial homeostasis and linked to Parkinson’s disease. In this issue, Gupta et al. (2017) demonstrate that PARK2 expression is frequently reduced in human cancers and that this alteration leads to dysregulated PI3K signaling. The PARK2 gene encodes an ubiquitin E3 ligase that is involved in mitochondrial homeostasis and linked to Parkinson’s disease. In this issue, Gupta et al. (2017) demonstrate that PARK2 expression is frequently reduced in human cancers and that this alteration leads to dysregulated PI3K signaling.
ISSN:1097-2765
1097-4164
DOI:10.1016/j.molcel.2017.02.030