Diethylstilbestrol induces oxidative DNA damage, resulting in apoptosis of spermatogonial stem cells in vitro

Highlights • Exposure of the spermatogonial stem cells to DES produced significant increases in superoxide anion, DNA damage and apoptosis. • The male reproductive system can be disrupted by foetal exposure to DES. • The flavonoid quercetin reduced intracellular superoxide anions induced by DES....

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Veröffentlicht in:	Toxicology (Amsterdam) 2017-05, Vol.382, p.117-121
Hauptverfasser:	Habas, Khaled, Brinkworth, Martin. H, Anderson, Diana
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Apoptosis - drug effects Cell Survival - drug effects Comet Assay Diethylstilbestrol Diethylstilbestrol - toxicity DNA Damage Emergency Estrogens, Non-Steroidal - toxicity Male Mice Oxidative Stress Quercetin Spermatogonia - drug effects Spermatogonia - metabolism Spermatogonial stem cells Superoxides - metabolism
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Zusammenfassung:	Highlights • Exposure of the spermatogonial stem cells to DES produced significant increases in superoxide anion, DNA damage and apoptosis. • The male reproductive system can be disrupted by foetal exposure to DES. • The flavonoid quercetin reduced intracellular superoxide anions induced by DES.
ISSN:	0300-483X 1879-3185
DOI:	10.1016/j.tox.2017.03.013