Impact of Maintenance Therapy for Patients with Non-small Cell Lung Cancer in a Real-world Setting

The purpose of this study was to explore the role of maintenance therapy for patients with advanced non-small cell lung cancer (NSCLC) in a real-world setting. This was a prospective observational cohort multicenter study. Eligible patients were observed from initiation of first-line platinum-based...

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Veröffentlicht in:Anticancer research 2017-03, Vol.37 (3), p.1507-1514
Hauptverfasser: Yoh, Kiyotaka, Goto, Yasushi, Naito, Yoichi, Kishi, Kazuma, Mori, Kiyoshi, Hotta, Katsuyuki, Hosomi, Yukio, Yamada, Kazuhiko, Tanai, Chiharu, Tomizawa, Yoshio, Inoue, Akira, Hasegawa, Yoshinori, Nishio, Makoto, Ohashi, Yasuo, Kunitoh, Hideo
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Sprache:eng
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Zusammenfassung:The purpose of this study was to explore the role of maintenance therapy for patients with advanced non-small cell lung cancer (NSCLC) in a real-world setting. This was a prospective observational cohort multicenter study. Eligible patients were observed from initiation of first-line platinum-based chemotherapy until final follow-up. Between 2010 and 2011, a total of 864 patients were enrolled in this study. The primary study population was 396 patients who had progressive disease during observation after first-line chemotherapy without maintenance. Of these, 113 patients (29%) did not receive second-line therapy. In contrast, only 18% of patients who had progressive disease during maintenance therapy missed second-line therapy. Overall survival of patients without maintenance who received second-line therapy was similar to that of those who received maintenance, but no second-line therapy. Maintenance therapy for patients with advanced NSCLC might be an appropriate strategy to maximize the chance of receiving more active therapy.
ISSN:0250-7005
1791-7530
DOI:10.21873/anticanres.11478