A Computational Comparison of the Multiple-breath Washout and Forced Oscillation Technique as Markers of Bronchoconstriction

A Computational Comparison of the Multiple-breath Washout and Forced Oscillation Technique as Markers of Bronchoconstriction

Highlights • FOT index R5 responds to constriction, regardless of depth. • Certain FOT indices respond strongly to distal airway constriction. • MBW indices respond strongly to severity of bronchoconstriction. • Joint-interpretation of MBW and FOT indices has potential utility.

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Bibliographische Detailangaben
Veröffentlicht in:Respiratory physiology & neurobiology 2017-06, Vol.240, p.61-69
Hauptverfasser: Foy, Brody H, Kay, David
Format: Artikel
Sprache:eng
Schlagworte:
Airway resistance
Airway Resistance - physiology
Bronchial Provocation Tests
Bronchoconstriction
Bronchoconstriction - physiology
Computer Simulation
Forced Expiratory Volume - physiology
Forced oscillation technique
Humans
Inert-gas washout
Medical Education
Models, Biological
Pulmonary Ventilation - physiology
Pulmonary/Respiratory
Respiratory Function Tests
Ventilation heterogeneity
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Beschreibung
Zusammenfassung:Highlights • FOT index R5 responds to constriction, regardless of depth. • Certain FOT indices respond strongly to distal airway constriction. • MBW indices respond strongly to severity of bronchoconstriction. • Joint-interpretation of MBW and FOT indices has potential utility.
ISSN:1569-9048
1878-1519
DOI:10.1016/j.resp.2017.02.016