Feasibility and toxicity of CCNU therapy in elderly patients with glioblastoma multiforme

In our institution, 103 glioblastoma multiforme (GBM) patients aged from 55 to 83 years were treated since November 1994 as follows. All patients underwent surgical intervention (gross total resection, n=35; subtotal resection, n=38; stereotactic biopsy, n=30). Subsequently all patients were offered...

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Veröffentlicht in:	Anti-cancer drugs 2003-02, Vol.14 (2), p.137-143
Hauptverfasser:	Piribauer, Maria, Fazeny-Dörner, Barbara, Rössler, Karl, Ungersböck, Karl, Czech, Thomas, Killer, Monika, Dieckmann, Karin, Birner, Peter, Prayer, Daniela, Hainfellner, Johannes, Muhm, Manfred, Marosi, Christine
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Antineoplastic Agents, Alkylating - adverse effects Antineoplastic Agents, Alkylating - therapeutic use Brain Neoplasms - drug therapy Brain Neoplasms - mortality Brain Neoplasms - pathology Disease Progression Feasibility Studies Female Glioblastoma - drug therapy Glioblastoma - mortality Glioblastoma - pathology Humans Lomustine - adverse effects Lomustine - therapeutic use Male Middle Aged Palliative Care Prognosis Prospective Studies Radiotherapy, Adjuvant Survival Rate
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Zusammenfassung:	In our institution, 103 glioblastoma multiforme (GBM) patients aged from 55 to 83 years were treated since November 1994 as follows. All patients underwent surgical intervention (gross total resection, n=35; subtotal resection, n=38; stereotactic biopsy, n=30). Subsequently all patients were offered radiotherapy and chemotherapy with CCNU. Results were as follows101 patients started radiotherapy, 93 patients completed it (96% of the patients aged
ISSN:	0959-4973 1473-5741
DOI:	10.1097/00001813-200302000-00007