The Influences of a Targeting Peptide on the Ovarian Cancer Cell Motility

Tumor metastasis is the major cause of death from ovarian cancer. Therefore, targeted therapy, which could prevent the ability of cells to metastasize to different organs, is an effective treatment for ovarian cancer at present. Previous study indicated that the peptide WSGPGVWGASVK (WSG) inhibited the adhesive ability of SK-OV-3 to extracellular matrix. For further study, we have investigated the effects of the peptide WSG on the ovarian cancer cell migration. Results showed that WSG peptide promoted the migration of SK-OV-3 and HUVEC cells through regulating the expression of talin and ( p )-paxilin protein. Besides, WSG peptide inhibited the SK-OV-3 viability. The expression of human matrix metalloproteinase MMP-2 and MMP-9 of SK-OV-3 cells was inhibited. All these results suggested that peptide WSG might be used in ovarian cancer therapy.