Discerning Risk of Disease Transition in Relatives of Systemic Lupus Erythematosus Patients Utilizing Soluble Mediators and Clinical Features

Discerning Risk of Disease Transition in Relatives of Systemic Lupus Erythematosus Patients Utilizing Soluble Mediators and Clinical Features

Objective Systemic lupus erythematosus (SLE) and other autoimmune diseases cause significant morbidity. Identifying populations at risk of developing SLE is essential for curtailing irreversible inflammatory damage. The aim of this study was to identify factors associated with transition to classifi...

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Veröffentlicht in:Arthritis & rheumatology (Hoboken, N.J.) N.J.), 2017-03, Vol.69 (3), p.630-642
Hauptverfasser: Munroe, Melissa E., Young, Kendra A., Kamen, Diane L., Guthridge, Joel M., Niewold, Timothy B., Costenbader, Karen H., Weisman, Michael H., Ishimori, Mariko L., Wallace, Daniel J., Gilkeson, Gary S., Karp, David R., Harley, John B., Norris, Jill M., James, Judith A.
Format: Artikel
Sprache:eng
Schlagworte:
Autoantibodies - blood
Autoimmune diseases
Chronic conditions
Classification
Connective tissues
Criteria
Damage detection
Demographics
Disease
Female
Follow-Up Studies
Health risks
Humans
Identification methods
Immunology
Inflammation Mediators - blood
Interferon
Interleukins
Lupus
Lupus Erythematosus, Systemic - blood
Lupus Erythematosus, Systemic - diagnosis
Lupus Erythematosus, Systemic - epidemiology
Lupus Erythematosus, Systemic - genetics
Male
Middle Aged
Morbidity
Patients
Plasmas (physics)
Rheumatology
Risk
Risk Assessment
Systemic lupus erythematosus
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Zusammenfassung:Objective Systemic lupus erythematosus (SLE) and other autoimmune diseases cause significant morbidity. Identifying populations at risk of developing SLE is essential for curtailing irreversible inflammatory damage. The aim of this study was to identify factors associated with transition to classified disease that would inform our understanding of the risk of SLE. Methods Previously identified blood relatives of patients with SLE, who had
ISSN:2326-5191
2326-5205
DOI:10.1002/art.40004