Changes in cardiac repolarisation during spontaneous nocturnal hypoglycaemia in subjects with type 1 diabetes: a preliminary report

Changes in cardiac repolarisation during spontaneous nocturnal hypoglycaemia in subjects with type 1 diabetes: a preliminary report

Aims Experimental studies have revealed that hypoglycaemia can result in morphological changes in electrocardiographic repolarisation in subjects with type 1 diabetes. However, the influence of spontaneous nocturnal hypoglycaemia on repolarisation morphology in a ‘real life’ situation is not clear....

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Veröffentlicht in:Acta diabetologica 2017-03, Vol.54 (3), p.251-256
Hauptverfasser: Koivikko, Minna L., Kenttä, Tuomas, Salmela, Pasi I., Huikuri, Heikki V., Perkiömäki, Juha S.
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Arrhythmias, Cardiac - epidemiology
Arrhythmias, Cardiac - etiology
Arrhythmias, Cardiac - physiopathology
Blood Glucose - physiology
Blood Glucose Self-Monitoring
Case-Control Studies
Circadian Rhythm - drug effects
Circadian Rhythm - physiology
Diabetes
Diabetes Mellitus, Type 1 - blood
Diabetes Mellitus, Type 1 - complications
Diabetes Mellitus, Type 1 - drug therapy
Diabetes Mellitus, Type 1 - physiopathology
Electrocardiography
Female
Glucose
Heart - physiopathology
Heart Rate - drug effects
Heart Rate - physiology
Humans
Hypoglycemia
Hypoglycemia - chemically induced
Hypoglycemia - epidemiology
Hypoglycemia - physiopathology
Incidence
Internal Medicine
Male
Medicine
Medicine & Public Health
Metabolic Diseases
Morphology
Original Article
Pilot Projects
Young Adult
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Zusammenfassung:Aims Experimental studies have revealed that hypoglycaemia can result in morphological changes in electrocardiographic repolarisation in subjects with type 1 diabetes. However, the influence of spontaneous nocturnal hypoglycaemia on repolarisation morphology in a ‘real life’ situation is not clear. Methods Adults with type 1 diabetes ( n  = 11) underwent continuous glucose monitoring with a subcutaneous sensor and digital 12-lead ECG recording for three nights. T-wave morphology was analysed with custom-made software during both hypoglycaemia (glucose
ISSN:0940-5429
1432-5233
DOI:10.1007/s00592-016-0941-2