Enzymes Beat Chemists in the Formation of an Unnatural Bond

A fundamental difference? A heme protein known to catalyze electron transfers was engineered into an enzyme that catalyzes the formation of C−Si bonds with >99 % ee. The new enzyme uses diazoesters as carbene donors for the insertion of various silanes into the Si−H bond. This is the first report...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Chembiochem : a European journal of chemical biology 2017-03, Vol.18 (5), p.432-434
Hauptverfasser:	Ducharme, Julie, Auclair, Karine
Format:	Artikel
Sprache:	eng
Schlagworte:	C-Si bonds Catalysis Chemistry Techniques, Analytical - methods enzyme engineering Enzymes Enzymes - genetics Enzymes - metabolism Esters - metabolism Heme - genetics Heme - metabolism heme proteins mutagenesis organosilicon Organosilicon Compounds - metabolism Protein Engineering Silanes - chemistry
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	A fundamental difference? A heme protein known to catalyze electron transfers was engineered into an enzyme that catalyzes the formation of C−Si bonds with >99 % ee. The new enzyme uses diazoesters as carbene donors for the insertion of various silanes into the Si−H bond. This is the first reported organosilicon‐producing enzyme.
ISSN:	1439-4227 1439-7633
DOI:	10.1002/cbic.201600692