Protective effects of Aloe sterols against UVB‐induced photoaging in hairless mice
Summary Background Aloe vera is a traditional medical plant whose gel has been widely used in skin care. Previously, we have identified Aloe sterols from Aloe vera as active ingredients. This study investigated the protective effects of Aloe sterols without polysaccharides, against ultraviolet B (UV...
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| Veröffentlicht in: | Photodermatology, photoimmunology & photomedicine photoimmunology & photomedicine, 2017-03, Vol.33 (2), p.101-111 |
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| container_title | Photodermatology, photoimmunology & photomedicine |
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| creator | Misawa, Eriko Tanaka, Miyuki Saito, Marie Nabeshima, Kazumi Yao, Ruiqing Yamauchi, Kouji Abe, Fumiaki Yamamoto, Yuki Furukawa, Fukumi |
| description | Summary
Background
Aloe vera is a traditional medical plant whose gel has been widely used in skin care. Previously, we have identified Aloe sterols from Aloe vera as active ingredients. This study investigated the protective effects of Aloe sterols without polysaccharides, against ultraviolet B (UVB)‐induced skin photoaging in mice using Aloe vera gel extract (AVGE) obtained by supercritical fluid extraction.
Methods
Aloe vera gel extract was supplemented in the diet (12 or 120 ppm), and HR‐1 hairless mice were exposed to UVB irradiation for 7 weeks. Skin measurements and histological and analytical studies were performed.
Results
Repeated UVB irradiation induced rough wrinkling of skin with water content reduction and hyperkeratosis. AVGE administration resulted in the significant improvement of UVB‐induced skin dryness, epidermal thickness, and wrinkle formation. The AVGE group also suppressed the degenerations of dermal collagen fibers and the appearance of cutaneous apoptosis cells induced by UVB. Furthermore, AVGE administration reduced the excess elevation of pro‐inflammatory cytokines (IL‐1β and TNF‐α) and matrix metalloproteinases (MMP‐2, MMP‐9, MMP‐12, and MMP‐13) in UVB‐exposed skin.
Conclusion
The dietary ingestion of Aloe sterols protected against chronic UVB damage in mouse skin, and our results suggest that Aloe sterols may prevent skin photoaging through the anti‐inflammation and MMP regulation. |
| doi_str_mv | 10.1111/phpp.12286 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1877814698</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1877814698</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4286-f5dca38aba9cf403eb3e0833dcb3cc18ddfac7afcc8e404cae6365a9c2700fcf3</originalsourceid><addsrcrecordid>eNqNkL1OwzAQgC0EoqWw8ADII0JKseP8OGOpgCJVIkPLGjnOuTVK4xAnoG48As_Ik-CSwoi45W749On0IXROyZi6ua7XdT2mvs-jAzSkESEeiTk9REOSkNALGGcDdGLtMyEkCAg9RgM_TpIwCuMhWqSNaUG2-hUwKOUui43Ck9IAti00prRYrISubIuXTzef7x-6KjoJBa7XpjVipasV1hVeC92UYC3eaAmn6EiJ0sLZfo_Q8u52MZ1588f7h-lk7snAPeupsJCCcZGLRKqAMMgZEM5YIXMmJeVFoYSMhZKSQ0ACKSBiUehgPyZEScVG6LL31o156cC22UZbCWUpKjCdzSiPXYggSvg_0JD6SRKHoUOvelQ2xtoGVFY3eiOabUZJtgue7YJn38EdfLH3dvkGil_0p7ADaA-86RK2f6iydJamvfQLv-eN3Q</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1851299755</pqid></control><display><type>article</type><title>Protective effects of Aloe sterols against UVB‐induced photoaging in hairless mice</title><source>MEDLINE</source><source>Wiley Journals</source><creator>Misawa, Eriko ; Tanaka, Miyuki ; Saito, Marie ; Nabeshima, Kazumi ; Yao, Ruiqing ; Yamauchi, Kouji ; Abe, Fumiaki ; Yamamoto, Yuki ; Furukawa, Fukumi</creator><creatorcontrib>Misawa, Eriko ; Tanaka, Miyuki ; Saito, Marie ; Nabeshima, Kazumi ; Yao, Ruiqing ; Yamauchi, Kouji ; Abe, Fumiaki ; Yamamoto, Yuki ; Furukawa, Fukumi</creatorcontrib><description>Summary
Background
Aloe vera is a traditional medical plant whose gel has been widely used in skin care. Previously, we have identified Aloe sterols from Aloe vera as active ingredients. This study investigated the protective effects of Aloe sterols without polysaccharides, against ultraviolet B (UVB)‐induced skin photoaging in mice using Aloe vera gel extract (AVGE) obtained by supercritical fluid extraction.
Methods
Aloe vera gel extract was supplemented in the diet (12 or 120 ppm), and HR‐1 hairless mice were exposed to UVB irradiation for 7 weeks. Skin measurements and histological and analytical studies were performed.
Results
Repeated UVB irradiation induced rough wrinkling of skin with water content reduction and hyperkeratosis. AVGE administration resulted in the significant improvement of UVB‐induced skin dryness, epidermal thickness, and wrinkle formation. The AVGE group also suppressed the degenerations of dermal collagen fibers and the appearance of cutaneous apoptosis cells induced by UVB. Furthermore, AVGE administration reduced the excess elevation of pro‐inflammatory cytokines (IL‐1β and TNF‐α) and matrix metalloproteinases (MMP‐2, MMP‐9, MMP‐12, and MMP‐13) in UVB‐exposed skin.
Conclusion
The dietary ingestion of Aloe sterols protected against chronic UVB damage in mouse skin, and our results suggest that Aloe sterols may prevent skin photoaging through the anti‐inflammation and MMP regulation.</description><identifier>ISSN: 0905-4383</identifier><identifier>EISSN: 1600-0781</identifier><identifier>DOI: 10.1111/phpp.12286</identifier><identifier>PMID: 27995657</identifier><language>eng</language><publisher>England</publisher><subject>Aloe ; Aloe vera ; Aloe vera gel ; Animals ; Apoptosis - drug effects ; Apoptosis - radiation effects ; Collagen - metabolism ; Epidermis - drug effects ; Epidermis - metabolism ; Epidermis - pathology ; Female ; Gels ; Interleukin-1beta - metabolism ; Matrix Metalloproteinases - metabolism ; Mice ; Mice, Hairless ; photoaging ; Plant Extracts - pharmacology ; plant sterols ; Protective Agents - pharmacology ; Skin Aging - drug effects ; Skin Aging - pathology ; Skin Aging - radiation effects ; Sterols - pharmacology ; Tumor Necrosis Factor-alpha - metabolism ; Ultraviolet Rays - adverse effects ; Water Loss, Insensible</subject><ispartof>Photodermatology, photoimmunology & photomedicine, 2017-03, Vol.33 (2), p.101-111</ispartof><rights>2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><rights>2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4286-f5dca38aba9cf403eb3e0833dcb3cc18ddfac7afcc8e404cae6365a9c2700fcf3</citedby><cites>FETCH-LOGICAL-c4286-f5dca38aba9cf403eb3e0833dcb3cc18ddfac7afcc8e404cae6365a9c2700fcf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fphpp.12286$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fphpp.12286$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27995657$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Misawa, Eriko</creatorcontrib><creatorcontrib>Tanaka, Miyuki</creatorcontrib><creatorcontrib>Saito, Marie</creatorcontrib><creatorcontrib>Nabeshima, Kazumi</creatorcontrib><creatorcontrib>Yao, Ruiqing</creatorcontrib><creatorcontrib>Yamauchi, Kouji</creatorcontrib><creatorcontrib>Abe, Fumiaki</creatorcontrib><creatorcontrib>Yamamoto, Yuki</creatorcontrib><creatorcontrib>Furukawa, Fukumi</creatorcontrib><title>Protective effects of Aloe sterols against UVB‐induced photoaging in hairless mice</title><title>Photodermatology, photoimmunology & photomedicine</title><addtitle>Photodermatol Photoimmunol Photomed</addtitle><description>Summary
Background
Aloe vera is a traditional medical plant whose gel has been widely used in skin care. Previously, we have identified Aloe sterols from Aloe vera as active ingredients. This study investigated the protective effects of Aloe sterols without polysaccharides, against ultraviolet B (UVB)‐induced skin photoaging in mice using Aloe vera gel extract (AVGE) obtained by supercritical fluid extraction.
Methods
Aloe vera gel extract was supplemented in the diet (12 or 120 ppm), and HR‐1 hairless mice were exposed to UVB irradiation for 7 weeks. Skin measurements and histological and analytical studies were performed.
Results
Repeated UVB irradiation induced rough wrinkling of skin with water content reduction and hyperkeratosis. AVGE administration resulted in the significant improvement of UVB‐induced skin dryness, epidermal thickness, and wrinkle formation. The AVGE group also suppressed the degenerations of dermal collagen fibers and the appearance of cutaneous apoptosis cells induced by UVB. Furthermore, AVGE administration reduced the excess elevation of pro‐inflammatory cytokines (IL‐1β and TNF‐α) and matrix metalloproteinases (MMP‐2, MMP‐9, MMP‐12, and MMP‐13) in UVB‐exposed skin.
Conclusion
The dietary ingestion of Aloe sterols protected against chronic UVB damage in mouse skin, and our results suggest that Aloe sterols may prevent skin photoaging through the anti‐inflammation and MMP regulation.</description><subject>Aloe</subject><subject>Aloe vera</subject><subject>Aloe vera gel</subject><subject>Animals</subject><subject>Apoptosis - drug effects</subject><subject>Apoptosis - radiation effects</subject><subject>Collagen - metabolism</subject><subject>Epidermis - drug effects</subject><subject>Epidermis - metabolism</subject><subject>Epidermis - pathology</subject><subject>Female</subject><subject>Gels</subject><subject>Interleukin-1beta - metabolism</subject><subject>Matrix Metalloproteinases - metabolism</subject><subject>Mice</subject><subject>Mice, Hairless</subject><subject>photoaging</subject><subject>Plant Extracts - pharmacology</subject><subject>plant sterols</subject><subject>Protective Agents - pharmacology</subject><subject>Skin Aging - drug effects</subject><subject>Skin Aging - pathology</subject><subject>Skin Aging - radiation effects</subject><subject>Sterols - pharmacology</subject><subject>Tumor Necrosis Factor-alpha - metabolism</subject><subject>Ultraviolet Rays - adverse effects</subject><subject>Water Loss, Insensible</subject><issn>0905-4383</issn><issn>1600-0781</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkL1OwzAQgC0EoqWw8ADII0JKseP8OGOpgCJVIkPLGjnOuTVK4xAnoG48As_Ik-CSwoi45W749On0IXROyZi6ua7XdT2mvs-jAzSkESEeiTk9REOSkNALGGcDdGLtMyEkCAg9RgM_TpIwCuMhWqSNaUG2-hUwKOUui43Ck9IAti00prRYrISubIuXTzef7x-6KjoJBa7XpjVipasV1hVeC92UYC3eaAmn6EiJ0sLZfo_Q8u52MZ1588f7h-lk7snAPeupsJCCcZGLRKqAMMgZEM5YIXMmJeVFoYSMhZKSQ0ACKSBiUehgPyZEScVG6LL31o156cC22UZbCWUpKjCdzSiPXYggSvg_0JD6SRKHoUOvelQ2xtoGVFY3eiOabUZJtgue7YJn38EdfLH3dvkGil_0p7ADaA-86RK2f6iydJamvfQLv-eN3Q</recordid><startdate>201703</startdate><enddate>201703</enddate><creator>Misawa, Eriko</creator><creator>Tanaka, Miyuki</creator><creator>Saito, Marie</creator><creator>Nabeshima, Kazumi</creator><creator>Yao, Ruiqing</creator><creator>Yamauchi, Kouji</creator><creator>Abe, Fumiaki</creator><creator>Yamamoto, Yuki</creator><creator>Furukawa, Fukumi</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>201703</creationdate><title>Protective effects of Aloe sterols against UVB‐induced photoaging in hairless mice</title><author>Misawa, Eriko ; Tanaka, Miyuki ; Saito, Marie ; Nabeshima, Kazumi ; Yao, Ruiqing ; Yamauchi, Kouji ; Abe, Fumiaki ; Yamamoto, Yuki ; Furukawa, Fukumi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4286-f5dca38aba9cf403eb3e0833dcb3cc18ddfac7afcc8e404cae6365a9c2700fcf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Aloe</topic><topic>Aloe vera</topic><topic>Aloe vera gel</topic><topic>Animals</topic><topic>Apoptosis - drug effects</topic><topic>Apoptosis - radiation effects</topic><topic>Collagen - metabolism</topic><topic>Epidermis - drug effects</topic><topic>Epidermis - metabolism</topic><topic>Epidermis - pathology</topic><topic>Female</topic><topic>Gels</topic><topic>Interleukin-1beta - metabolism</topic><topic>Matrix Metalloproteinases - metabolism</topic><topic>Mice</topic><topic>Mice, Hairless</topic><topic>photoaging</topic><topic>Plant Extracts - pharmacology</topic><topic>plant sterols</topic><topic>Protective Agents - pharmacology</topic><topic>Skin Aging - drug effects</topic><topic>Skin Aging - pathology</topic><topic>Skin Aging - radiation effects</topic><topic>Sterols - pharmacology</topic><topic>Tumor Necrosis Factor-alpha - metabolism</topic><topic>Ultraviolet Rays - adverse effects</topic><topic>Water Loss, Insensible</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Misawa, Eriko</creatorcontrib><creatorcontrib>Tanaka, Miyuki</creatorcontrib><creatorcontrib>Saito, Marie</creatorcontrib><creatorcontrib>Nabeshima, Kazumi</creatorcontrib><creatorcontrib>Yao, Ruiqing</creatorcontrib><creatorcontrib>Yamauchi, Kouji</creatorcontrib><creatorcontrib>Abe, Fumiaki</creatorcontrib><creatorcontrib>Yamamoto, Yuki</creatorcontrib><creatorcontrib>Furukawa, Fukumi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Photodermatology, photoimmunology & photomedicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Misawa, Eriko</au><au>Tanaka, Miyuki</au><au>Saito, Marie</au><au>Nabeshima, Kazumi</au><au>Yao, Ruiqing</au><au>Yamauchi, Kouji</au><au>Abe, Fumiaki</au><au>Yamamoto, Yuki</au><au>Furukawa, Fukumi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Protective effects of Aloe sterols against UVB‐induced photoaging in hairless mice</atitle><jtitle>Photodermatology, photoimmunology & photomedicine</jtitle><addtitle>Photodermatol Photoimmunol Photomed</addtitle><date>2017-03</date><risdate>2017</risdate><volume>33</volume><issue>2</issue><spage>101</spage><epage>111</epage><pages>101-111</pages><issn>0905-4383</issn><eissn>1600-0781</eissn><abstract>Summary
Background
Aloe vera is a traditional medical plant whose gel has been widely used in skin care. Previously, we have identified Aloe sterols from Aloe vera as active ingredients. This study investigated the protective effects of Aloe sterols without polysaccharides, against ultraviolet B (UVB)‐induced skin photoaging in mice using Aloe vera gel extract (AVGE) obtained by supercritical fluid extraction.
Methods
Aloe vera gel extract was supplemented in the diet (12 or 120 ppm), and HR‐1 hairless mice were exposed to UVB irradiation for 7 weeks. Skin measurements and histological and analytical studies were performed.
Results
Repeated UVB irradiation induced rough wrinkling of skin with water content reduction and hyperkeratosis. AVGE administration resulted in the significant improvement of UVB‐induced skin dryness, epidermal thickness, and wrinkle formation. The AVGE group also suppressed the degenerations of dermal collagen fibers and the appearance of cutaneous apoptosis cells induced by UVB. Furthermore, AVGE administration reduced the excess elevation of pro‐inflammatory cytokines (IL‐1β and TNF‐α) and matrix metalloproteinases (MMP‐2, MMP‐9, MMP‐12, and MMP‐13) in UVB‐exposed skin.
Conclusion
The dietary ingestion of Aloe sterols protected against chronic UVB damage in mouse skin, and our results suggest that Aloe sterols may prevent skin photoaging through the anti‐inflammation and MMP regulation.</abstract><cop>England</cop><pmid>27995657</pmid><doi>10.1111/phpp.12286</doi><tpages>11</tpages></addata></record> |
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| identifier | ISSN: 0905-4383 |
| ispartof | Photodermatology, photoimmunology & photomedicine, 2017-03, Vol.33 (2), p.101-111 |
| issn | 0905-4383 1600-0781 |
| language | eng |
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| source | MEDLINE; Wiley Journals |
| subjects | Aloe Aloe vera Aloe vera gel Animals Apoptosis - drug effects Apoptosis - radiation effects Collagen - metabolism Epidermis - drug effects Epidermis - metabolism Epidermis - pathology Female Gels Interleukin-1beta - metabolism Matrix Metalloproteinases - metabolism Mice Mice, Hairless photoaging Plant Extracts - pharmacology plant sterols Protective Agents - pharmacology Skin Aging - drug effects Skin Aging - pathology Skin Aging - radiation effects Sterols - pharmacology Tumor Necrosis Factor-alpha - metabolism Ultraviolet Rays - adverse effects Water Loss, Insensible |
| title | Protective effects of Aloe sterols against UVB‐induced photoaging in hairless mice |
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