FORMULATION AND EVALUTION OF LANSOPRAZOLE ORODISPERSABLE TABLETS

Lansoprazole a proton pump inhibitor used in the short term treatment of gastric and duodenal ulcer, reflux esophagitis, structuring and erosive esophagitis. In the present investigation an attempt has been made to enhance the solubility and dissolution rate of lansprozole by formulating it as solid dispersions with KollidonVA64, Soluplus and poly ethylene glycol 6000 by solvent evaporation method. The solid dispersions were further compressed as tablets by using superdisintegrants such as croscarmellose sodium (CCS) & crospovidone (CP). Rapid release of lansoprazole from solid dispersions was observed which was influenced by the proportion of carrier concentration. Among the solid dispersions prepared the dispersion formulated using Soluplus showed rapid drug release than kollidon & PEG 6000 containing Solid dispersions and pure drug alone. The release was found to follow the first order kinetics. Solid dispersions prepared by the solvent evaporation method were further formulated into tablets with superdisintegrants such as croscarmellose sodium, crospovidone. The dissolution rate of such tablet formulations were found to release the drug at a faster rate than the tablets prepared with plain drug.