Hair analysis reveals subtle HPA axis suppression associated with use of local corticosteroids: The Lifelines cohort study

Highlights • Influences of glucocorticoid containing medications and stressful life events on long-term (hair) glucocorticoids are not fully unraveled. • We measured hair glucocorticoids in 295 participants of a population-based cohort study. • Hair cortisone is lower in participants using locally a...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Psychoneuroendocrinology 2017-06, Vol.80, p.1-6
Hauptverfasser:	Wester, Vincent L, Noppe, Gerard, Savas, Mesut, van den Akker, Erica L.T, de Rijke, Yolanda B, van Rossum, Elisabeth F.C
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenal Cortex Hormones - metabolism Adult Aged Cohort Studies Corticosteroids Cortisone - analysis Endocrinology & Metabolism Female Gas Chromatography-Mass Spectrometry Glucocorticoids Glucocorticoids - analysis Glucocorticoids - metabolism Hair - chemistry Hair Color Hair cortisol Hair cortisone Humans Hydrocortisone - analysis Hypothalamo-Hypophyseal System - metabolism Life events Male Middle Aged Netherlands Pituitary-Adrenal System - metabolism Psychiatry Stress, Psychological - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Highlights • Influences of glucocorticoid containing medications and stressful life events on long-term (hair) glucocorticoids are not fully unraveled. • We measured hair glucocorticoids in 295 participants of a population-based cohort study. • Hair cortisone is lower in participants using locally administered corticosteroids, indicating that these medications have systemic effects. • For the first time, we report that hair cortisol is increased after stressful life events in a population-based cohort.
ISSN:	0306-4530 1873-3360
DOI:	10.1016/j.psyneuen.2017.02.024