Novel Discoveries and Advances in Management of Acute Respiratory Distress Syndrome

LIPS-A) conducted a multicenter, double-blind, placebo-controlled, randomized phase 2b clinical trial to determine whether prophylactic treatment with oral aspirin may reduce the incidence of ARDS in at-risk patients (1). Epidemiology, patterns of care, and mortality for patients with acute respiratory distress syndrome in intensive care units in 50 countries. Prehospitalization antiplatelet therapy is associated with a reduced incidence of acute lung injury: a population-based cohort study. In animal models of shock and ischemia-reperfusion injury, depletion of microbiota from the gastrointestinal tract attenuates the development of lung inflammation and improves survival (9-11). In their study, Dickson and colleagues (8) demonstrated that after cecal ligation and puncture (CLP), a murine model of sepsis and inflammation, the lung microbiome is distinctly altered from that of control mice and is more closely related to the gastrointestinal tract. Bronchoalveolar lavage (BAL) samples from mice that underwent CLP showed increased numbers of members of the Bacteroidales order, Enterococcus, Clostridiales, and Lachnospiraceae species, compared with healthy control mice or those who underwent sham surgery. Associations between ventilator settings during extracorporeal membrane oxygenation for refractory hypoxemia and outcome in patients with acute respiratory distress syndrome: a pooled individual patient data analysis: mechanical ventilation during ECMO. Position paper for the organization of extracorporeal membrane oxygenation programs for acute respiratory failure in adult patients.