The oil-rich alga Schizochytrium sp as a dietary source of docosahexaenoic acid improves shape discrimination learning associated with visual processing in a canine model of senescence

The oil-rich alga Schizochytrium sp as a dietary source of docosahexaenoic acid improves shape discrimination learning associated with visual processing in a canine model of senescence

Abstract Whole cell Schizochytrium sp. is a rich source of omega-3 long-chain polyunsaturated fatty acids (n-3 LCPUFA) including docosahexaenoic acid (DHA), an important nutrient for brain health. Aged beagle dogs experienced on a visuospatial task of working memory, variable-delay delayed-non-match...

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Veröffentlicht in:Prostaglandins, leukotrienes and essential fatty acids leukotrienes and essential fatty acids, 2017-03, Vol.118, p.10-18
Hauptverfasser: Hadley, K.B, Bauer, J, Milgram, N.W
Format: Artikel
Sprache:eng
Schlagworte:
Advanced Basic Science
Aging
Aging - blood
Aging - physiology
Algae
Animals
Cognitive function
Contrast sensitivity
Dietary Fats, Unsaturated - administration & dosage
Dinoprost - analogs & derivatives
Dinoprost - blood
Discrimination Learning
Disease Models, Animal
Docosahexaenoic acid
Docosahexaenoic Acids - administration & dosage
Dogs
Endocrinology & Metabolism
Humans
Memory
Memory, Short-Term
Omega-3
Phospholipids - blood
Schizochytrium
Senescence
Shape recognition
Stramenopiles - chemistry
Stramenopiles - physiology
Variable contrast
Visual processing
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Zusammenfassung:Abstract Whole cell Schizochytrium sp. is a rich source of omega-3 long-chain polyunsaturated fatty acids (n-3 LCPUFA) including docosahexaenoic acid (DHA), an important nutrient for brain health. Aged beagle dogs experienced on a visuospatial task of working memory, variable-delay delayed-non-matching-to-position were used to assess efficacy of DHA-rich microalgae based upon DHA wt% of total phospholipids and 8-iso-PGF2α concentrations in plasma, and performance on cognitive assessments of visual object discrimination, learning, and memory consolidation after 25 weeks on fortified diet. Improved DHA status (p
ISSN:0952-3278
1532-2823
DOI:10.1016/j.plefa.2017.01.011