Screening and characterization of astaxanthin-hyperproducing mutants of Haematococcus pluvialis

Haematococcus pluvialis was mutated by UV or ethyl methanesulphonate. Mutants resistant to nicotine, diphenylamine, fluridone or norflurazon were then selected. Several nicotine-resistant mutants showed increased (1.9% to 2.5% vs. 1.2% w/w) astaxanthin production. Mutants maintained high astaxanthin...

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Veröffentlicht in:	Biotechnology letters 2003-04, Vol.25 (7), p.527-529
Hauptverfasser:	Chen, Yong, Li, Defa, Lu, Wenqing, Xing, Jianjun, Hui, Bodi, Han, Yashan
Format:	Artikel
Sprache:	eng
Schlagworte:	beta Carotene - analogs & derivatives beta Carotene - biosynthesis Biological and medical sciences Biotechnology - methods Cell culture Chlorophyta - drug effects Chlorophyta - physiology Chlorophyta - radiation effects Diphenylamine - pharmacology Drug resistance Ethyl Methanesulfonate - pharmacology Fundamental and applied biological sciences. Psychology Mutagenesis Mutation Nicotine Nicotine - pharmacology Pyridazines - pharmacology Pyridones - pharmacology Ultraviolet Rays Xanthophylls
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Zusammenfassung:	Haematococcus pluvialis was mutated by UV or ethyl methanesulphonate. Mutants resistant to nicotine, diphenylamine, fluridone or norflurazon were then selected. Several nicotine-resistant mutants showed increased (1.9% to 2.5% vs. 1.2% w/w) astaxanthin production. Mutants maintained high astaxanthin production over 4 months of repeated culture.
ISSN:	0141-5492 1573-6776
DOI:	10.1023/A:1022877703008