The SMAC mimetic birinapant attenuates lipopolysaccharide-induced liver injury by inhibiting the tumor necrosis factor receptor–associated factor 3 degradation in Kupffer cells

Highlights • Birinapant significantly improved the survival rate of endotoxemic mice and attenuated LPS-induced liver pathologic damage. • Birinapant inhibited the expression of cIAP1, K48-linked polyubiquitination of TRAF3 and aviation of MAPK signaling pathway.

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Bibliographische Detailangaben
Veröffentlicht in:	Immunology letters 2017-05, Vol.185, p.79-83
Hauptverfasser:	Liu, Hongxiang, Liao, Rui, He, Kun, Zhu, Xiwen, Li, Peizhi, Gong, Jianping
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animals Biomimetics Birinapant Carrier Proteins - chemistry Chemical and Drug Induced Liver Injury - drug therapy Dipeptides - chemistry Dipeptides - therapeutic use Disease Models, Animal Endotoxemia - drug therapy Humans Indoles - chemistry Indoles - therapeutic use Inhibitor of Apoptosis Proteins - metabolism Interleukin-1 - blood Kupffer Cells - drug effects Kupffer Cells - immunology Lipopolysaccharides - immunology Liver - immunology Liver - pathology Liver injury Male MAP Kinase Signaling System Mice Mice, Inbred C57BL Mitochondrial Proteins - chemistry Proteolysis TNF Receptor-Associated Factor 3 - metabolism Tumor necrosis factor receptor-associated factor 3 Tumor Necrosis Factor-alpha - blood Ubiquitin-Protein Ligases - metabolism Ubiquitination
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Beschreibung
Zusammenfassung:	Highlights • Birinapant significantly improved the survival rate of endotoxemic mice and attenuated LPS-induced liver pathologic damage. • Birinapant inhibited the expression of cIAP1, K48-linked polyubiquitination of TRAF3 and aviation of MAPK signaling pathway.
ISSN:	0165-2478 1879-0542
DOI:	10.1016/j.imlet.2017.02.016