Role of thymic B cells in the development of thymus-derived regulatory T cell in vitro

Highlights • Thymic B cells in the condition of our experiments did not influence the generation of nTregs, but rather maintain their viability when activated by both activators. • Activated thymic B cells maintained the high percentage of nTreg generation or counteracted the decrease of this percen...

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Veröffentlicht in:	Immunology letters 2017-05, Vol.185, p.56-63
Hauptverfasser:	Muhammed Ali, Haider H, Muhammed Ali, Adnan H, Drela, Nadzieja
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Aminoquinolines - immunology Animals Antigens, CD - metabolism B-Lymphocytes - immunology Cell Differentiation Cells, Cultured Costimulatory molecules Forkhead Transcription Factors - genetics Forkhead Transcription Factors - metabolism Histocompatibility Antigens Class II - metabolism IMQ Lipopolysaccharides - immunology LPS Lymphocyte Activation Male MHC II Mice Mice, Inbred C57BL Mice, Knockout nTregs T-Lymphocyte Subsets - immunology T-Lymphocytes, Regulatory - immunology Thymic B cells Thymocytes - immunology Thymus Gland - immunology
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Zusammenfassung:	Highlights • Thymic B cells in the condition of our experiments did not influence the generation of nTregs, but rather maintain their viability when activated by both activators. • Activated thymic B cells maintained the high percentage of nTreg generation or counteracted the decrease of this percentage observed in non-activated culture. • Both activators (LPS and IMQ) have the same effect in the process of nTreg generation by B cells. • The percentage of B cells was strongly increased in the conditions of our experiments\72 h in LPS and IMQ-supplemented medium.
ISSN:	0165-2478 1879-0542
DOI:	10.1016/j.imlet.2017.03.007