Premature Ovarian Failure in French Canadian Leigh Syndrome

Premature Ovarian Failure in French Canadian Leigh Syndrome

In all surviving girls with Leigh syndrome, French Canadian variety, a mitochondrial disease, we detected premature ovarian failure, manifested as absent or arrested breast development, lack of menarche, high follicle-stimulating hormone, a prepubertal uterus, and small ovaries. Pubertal onset and p...

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Veröffentlicht in:The Journal of pediatrics 2017-05, Vol.184, p.227-229.e1
Hauptverfasser: Ghaddhab, Chiraz, MD, PhD, Morin, Charles, MD, Brunel-Guitton, Catherine, MD, Mitchell, Grant A., MD, Van Vliet, Guy, MD, Huot, Céline, MD, MSc
Format: Artikel
Sprache:eng
Schlagworte:
Adolescent
Canada
Female
Humans
Leigh Disease - classification
Leigh Disease - complications
metabolic acidosis
Pediatrics
premature ovarian failure
Primary Ovarian Insufficiency - etiology
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Zusammenfassung:In all surviving girls with Leigh syndrome, French Canadian variety, a mitochondrial disease, we detected premature ovarian failure, manifested as absent or arrested breast development, lack of menarche, high follicle-stimulating hormone, a prepubertal uterus, and small ovaries. Pubertal onset and progression should be evaluated in girls with mitochondrial diseases.
ISSN:0022-3476
1097-6833
DOI:10.1016/j.jpeds.2017.02.008