Significance of MDR1 gene C3435T polymorphism in predicting childhood refractory epilepsy

Significance of MDR1 gene C3435T polymorphism in predicting childhood refractory epilepsy

Highlights • The analysis showed that there were significantly more cases with the MDR1 3435 CC genotype in Caucasian. • The association of the MDR1 3435 CC genotype with risk of drug-resistance was significant in a ‘ > 2010’ group based on publication year subgroup analysis. • The allelic associ...

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Veröffentlicht in:Epilepsy research 2017-05, Vol.132, p.21-28
Hauptverfasser: Lv, Rui-Juan, Shao, Xiao-Qiu, Cui, Tao, Wang, Qun
Format: Artikel
Sprache:eng
Schlagworte:
ATP Binding Cassette Transporter, Sub-Family B - genetics
C3435T polymorphism
Childhood refractory epilepsy
Drug Resistance - genetics
Drug Resistance, Multiple - genetics
Epilepsy - genetics
European Continental Ancestry Group
Gene Frequency - genetics
Genetic Predisposition to Disease
Genotype
Humans
Meta-analysis
Multi-drug resistance 1 gene
Neurology
Polymorphism, Single Nucleotide - genetics
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Zusammenfassung:Highlights • The analysis showed that there were significantly more cases with the MDR1 3435 CC genotype in Caucasian. • The association of the MDR1 3435 CC genotype with risk of drug-resistance was significant in a ‘ > 2010’ group based on publication year subgroup analysis. • The allelic association of MDR1 C3435T with risk of drug-resistance was significant in Caucasian.
ISSN:0920-1211
1872-6844
DOI:10.1016/j.eplepsyres.2017.02.010