Purinergic P2 receptors in the paraventricular nucleus of the hypothalamus are involved in hyperosmotic-induced sympathoexcitation

Highlights • Increasing plasma osmolality activates P2X2-expressing neurons in the paraventricular nucleus. • Blocking P2 purinoceptors attenuate hyperosmotic activation of lumber sympathetic nerve activity. • P2 receptors are important for regulating sympathetic responses to increases in plasma osm...

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Veröffentlicht in:	Neuroscience 2017-05, Vol.349, p.253-263
Hauptverfasser:	Ferreira-Neto, H.C, Ribeiro, I.M.R, Moreira, T.S, Yao, S.T, Antunes, V.R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arginine Vasopressin - metabolism autonomic nervous system hyperosmolality hypertonic saline Hypothalamus - drug effects Hypothalamus - metabolism Male mannitol Neurology Neurons - drug effects Neurons - metabolism Paraventricular Hypothalamic Nucleus - drug effects purinergic signaling Rats, Wistar Receptors, Purinergic P2 - metabolism Saline Solution, Hypertonic - pharmacology sympathetic activity
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Zusammenfassung:	Highlights • Increasing plasma osmolality activates P2X2-expressing neurons in the paraventricular nucleus. • Blocking P2 purinoceptors attenuate hyperosmotic activation of lumber sympathetic nerve activity. • P2 receptors are important for regulating sympathetic responses to increases in plasma osmolality.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2017.02.054