Estrogen receptors ERα and ERβ participation in hypothalamus–pituitary–adrenal axis activation by hemorrhagic stress

Highlights • Gradual moderate hemorrhage increased corticosterone secretion, and ERα and ERβ receptor activation inhibited this response. • ERα agonist (PPT) treatment decreased corticosterone secretion in both control and hemorrhage situations. • ERβ agonist (DPN) treatment decreased corticosterone...

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Veröffentlicht in:	Neuroscience 2017-05, Vol.349, p.239-252
Hauptverfasser:	Alves, Luana Maria Silva, de Barcellos Filho, Procópio Cleber Gama, Franci, Celso Rodrigues
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Corticotropin-Releasing Hormone - metabolism ERα ERβ Estrogen Receptor alpha - metabolism Estrogen Receptor beta - metabolism Female FOS hemorrhage Hemorrhage - metabolism HPA axis Hypothalamo-Hypophyseal System - metabolism Neurology Paraventricular Hypothalamic Nucleus - metabolism Pituitary-Adrenal System - metabolism Rats, Wistar Receptors, Estrogen - metabolism Stress, Physiological - physiology tyrosine hydroxylase
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Beschreibung
Zusammenfassung:	Highlights • Gradual moderate hemorrhage increased corticosterone secretion, and ERα and ERβ receptor activation inhibited this response. • ERα agonist (PPT) treatment decreased corticosterone secretion in both control and hemorrhage situations. • ERβ agonist (DPN) treatment decreased corticosterone secretion only after hemorrhagic stress. • CRH neuron expression in paraventricular nucleus decreased after PPT or DPN treatment in rats with or without hemorrhage. • PPT or DPN treatment in rats with or without hemorrhage decreased CRH neuron expression in the paraventricular nucleus.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2017.03.001