The local administration of parathyroid hormone encourages the healing of bone defects in the rat calvaria: micro-computed tomography, histological and histomorphometric evaluation

Highlights • The local administration of PTH on bone healing in rat bone defects was evaluated. • Micro-CT, histological and histomorphometric analysis were performed. • At 15 days post-surgery, PTH Group exhibited higher percentage of bone formation. • The results suggest that PTH encouraged the in...

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Veröffentlicht in:	Archives of oral biology 2017-07, Vol.79, p.14-19
Hauptverfasser:	Auersvald, Caroline Moreira, Santos, Felipe Rychuv, Nakano, Mayara Mytie, Leoni, Graziela Bianchi, de Sousa Neto, Manoel Damião, Scariot, Rafaela, Giovanini, Allan Fernando, Deliberador, Tatiana Miranda
Format:	Artikel
Sprache:	eng
Schlagworte:	Advanced Basic Science Animals Bone regeneration Bone Regeneration - drug effects Calvaria Cattle Collagen - pharmacology Dentistry Male Micro-CT Osteogenesis - drug effects Parathyroid hormone Parathyroid Hormone - administration & dosage Parathyroid Hormone - pharmacology Rats Rats, Wistar Skull - diagnostic imaging Skull - drug effects Skull - pathology Skull - surgery Time Factors Wound Healing - drug effects X-Ray Microtomography - methods
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Zusammenfassung:	Highlights • The local administration of PTH on bone healing in rat bone defects was evaluated. • Micro-CT, histological and histomorphometric analysis were performed. • At 15 days post-surgery, PTH Group exhibited higher percentage of bone formation. • The results suggest that PTH encouraged the initial bone healing in bone defects.
ISSN:	0003-9969 1879-1506
DOI:	10.1016/j.archoralbio.2017.02.016