Enhanced TGFα-EGFR expression and P53 gene alterations contributes to gastric tumors aggressiveness

Enhanced TGFα-EGFR expression and P53 gene alterations contributes to gastric tumors aggressiveness

We determined whether alterations in the expression of p53, p16 INK4 and p21 WAF1/CIP1 influence the invasiveness of a subset of gastric adenocarcinomas co-expressing TGFα and EGFR. Immunopositivity for TGFα-EGFR (26%) was observed in both early and advanced adenocarcinomas, and 88% of these showed...

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Veröffentlicht in:Cancer letters 2004-08, Vol.212 (1), p.33-41
Hauptverfasser: Espinoza, Luis A, Tone, Luiz Gonzaga, Neto, José Barbieri, Costa, Roberto Silva, Wang, Qiming J, Ballejo, Gustavo
Format: Artikel
Sprache:eng
Schlagworte:
EGFR
Gastric adenocarcinomas
p16 INK4
p21 WAF1/CIP1
p53
TGFα
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Zusammenfassung:We determined whether alterations in the expression of p53, p16 INK4 and p21 WAF1/CIP1 influence the invasiveness of a subset of gastric adenocarcinomas co-expressing TGFα and EGFR. Immunopositivity for TGFα-EGFR (26%) was observed in both early and advanced adenocarcinomas, and 88% of these showed immunoreactivity for p53. SSCP analysis revealed that in 81% of these tumors the p53 gene was mutated in exons 5–8. The intensity of p53 immunoreactivity was significantly higher ( P
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2004.03.037