Yttrium‐Catalyzed Intramolecular Hydroalkoxylation/Claisen Rearrangement Sequence: Efficient Synthesis of Medium‐Sized Lactams

An efficient yttrium‐catalyzed intramolecular hydroalkoxylation/Claisen rearrangement sequence has been achieved, thus enabling facile access to a diverse array of valuable medium‐sized lactams. Furthermore, a mechanistic rationale for this novel cascade reaction is well supported by a variety of control experiments. Ring maker: An efficient yttrium‐catalyzed tandem intramolecular hydroxyalkylation/Claisen rearrangement has been achieved, enabling facile access to a diverse array of valuable medium‐sized lactams. A mechanistic rationale for this novel reaction sequence is well supported by a variety of control experiments.