IL-6 and TNF-α in unmedicated adults with ADHD: relationship to cortisol awakening response

Highlights • The pro-inflammatory markers, IL-6 and TNF-α, do not appear to be primarily involved in adult ADHD. • There are ADHD subtype differences in the association between IL-6 and TNF-α, and cortisol awakening response. • The predominantly inattentive adults with ADHD showed negative correlati...

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Veröffentlicht in:	Psychoneuroendocrinology 2017-05, Vol.79, p.67-73
Hauptverfasser:	Corominas-Roso, M, Armario, A, Palomar, G, Corrales, M, Carrasco, J, Richarte, V, Ferrer, R, Casas, M, Ramos, J.A
Format:	Artikel
Sprache:	eng
Schlagworte:	ADHD Adolescent Adult Attention Deficit Disorder with Hyperactivity - blood Attention Deficit Disorder with Hyperactivity - physiopathology Attention deficit hyperactivity disorder Biomarkers - blood Cortisol Cytokines Endocrinology & Metabolism Female Humans Hydrocortisone - analysis Hypothalamo-Hypophyseal System - physiopathology Il-6 Interleukin-6 - blood Male Middle Aged Pituitary-Adrenal System - physiopathology Psychiatry Saliva - chemistry TNF-α Tumor Necrosis Factor-alpha - blood Young Adult
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Zusammenfassung:	Highlights • The pro-inflammatory markers, IL-6 and TNF-α, do not appear to be primarily involved in adult ADHD. • There are ADHD subtype differences in the association between IL-6 and TNF-α, and cortisol awakening response. • The predominantly inattentive adults with ADHD showed negative correlations between CAR and both IL-6 and TNF-α. • The inattentive and combined subtypes might have distinct neurobiological profiles regarding IL-6 and TNF-alpha and its association in basal cortisol.
ISSN:	0306-4530 1873-3360
DOI:	10.1016/j.psyneuen.2017.02.017