Iriomoteolides-9a and 11a: two new odd-numbered macrolides from the marine dinoflagellate Amphidinium species

Iriomoteolides-9a and 11a: two new odd-numbered macrolides from the marine dinoflagellate Amphidinium species

Iriomoteolides-9a ( 1 ) and 11a ( 2 ), new 15- and 19-membered macrolides, respectively, have been isolated from the marine dinoflagellate Amphidinium species (strain KCA09052). Compounds 1 and 2 were obtained from the extracts of the algal cells inoculated in the PES and TKF seawater medium, respec...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Journal of natural medicines 2017-07, Vol.71 (3), p.506-512
Hauptverfasser: Kumagai, Keiko, Tsuda, Masayuki, Fukushi, Eri, Kawabata, Jun, Masuda, Atsunori, Tsuda, Masashi
Format: Artikel
Sprache:eng
Schlagworte:
Adenocarcinoma - drug therapy
Algae
Animals
Antibiotics
Antineoplastic Agents - chemistry
Antineoplastic Agents - isolation & purification
Antineoplastic Agents - pharmacology
Biological Products - chemistry
Biological Products - isolation & purification
Biological Products - pharmacology
Biomedical and Life Sciences
Biomedicine
Complementary & Alternative Medicine
Dinoflagellida - chemistry
Female
HeLa Cells
Humans
Macrolides - chemistry
Macrolides - isolation & purification
Macrolides - pharmacology
Magnetic Resonance Spectroscopy
Medicinal Chemistry
Microorganisms
Molecular Structure
Original Paper
Pharmacology/Toxicology
Pharmacy
Phytochemicals
Plant Sciences
Uterine Cervical Neoplasms - drug therapy
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Iriomoteolides-9a ( 1 ) and 11a ( 2 ), new 15- and 19-membered macrolides, respectively, have been isolated from the marine dinoflagellate Amphidinium species (strain KCA09052). Compounds 1 and 2 were obtained from the extracts of the algal cells inoculated in the PES and TKF seawater medium, respectively. The structures of 1 and 2 were assigned on the basis of detailed NMR analyses. Compounds 1 and 2 exhibited cytotoxic activity against human cervix adenocarcinoma HeLa cells.
ISSN:1340-3443
1861-0293
DOI:10.1007/s11418-017-1080-y