Resveratrol ameliorates hyperglycemia-induced renal tubular oxidative stress damage via modulating the SIRT1/FOXO3a pathway

Highlights • Hyperglycemia can induce oxidative stress damage in the kidney of rats and HK-2 cells. • Resveratrol could alleviate the oxidative stress damage which was caused by hyperglycemia. • SIRT1 was involved in the mechanism of resveratrol reducing the hyperglycemia-induced oxidative stress da...

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Veröffentlicht in:	Diabetes research and clinical practice 2017-04, Vol.126, p.172-181
Hauptverfasser:	Wang, Xueling, Meng, Linghang, Zhao, Long, Wang, Zengfu, Liu, Haiying, Liu, Gang, Guan, Guangju
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Catalase - metabolism Cytoprotection - drug effects Deacetylation Diabetic Nephropathies - metabolism Diabetic Nephropathies - pathology Diabetic Nephropathies - prevention & control Diabetic nephropathy Endocrinology & Metabolism Forkhead Box Protein O3 - metabolism FOXO3a Hyperglycemia - complications Hyperglycemia - metabolism Kidney Tubules - drug effects Kidney Tubules - metabolism Kidney Tubules - pathology Male Oxidative stress Oxidative Stress - drug effects Rats Rats, Wistar Reactive Oxygen Species - metabolism Resveratrol Signal Transduction - drug effects SIRT1 Sirtuin 1 - metabolism Stilbenes - pharmacology Superoxide Dismutase - metabolism
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Zusammenfassung:	Highlights • Hyperglycemia can induce oxidative stress damage in the kidney of rats and HK-2 cells. • Resveratrol could alleviate the oxidative stress damage which was caused by hyperglycemia. • SIRT1 was involved in the mechanism of resveratrol reducing the hyperglycemia-induced oxidative stress damage. • RSV modulates the SIRT1/FOXO3a pathway by increasing the SIRT1deacetylase activity, subsequently ameliorating hyperglycemia-induced renal tubular oxidative stress damage.
ISSN:	0168-8227 1872-8227
DOI:	10.1016/j.diabres.2016.12.005