The association of nonalcoholic fatty liver disease with genetic polymorphisms: a multicenter study

INTRODUCTIONGrowing evidence suggests that multiple factors, such as insulin resistance, nutritional factors, gut microbiota, and hormones released from the adipose tissue, act together on genetically predisposed individuals. We aimed to investigate whether various single-nucleotide polymorphisms (S...

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Veröffentlicht in:European journal of gastroenterology & hepatology 2017-04, Vol.29 (4), p.441-447
Hauptverfasser: Uygun, Ahmet, Ozturk, Kadir, Demirci, Hakan, Oztuna, Ali, Eren, Fatih, Kozan, Salih, Yilmaz, Yusuf, Kurt, Omer, Turker, Turker, Vatansever, Sezgin, Alper, Emrah, Unsal, Belkis
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Sprache:eng
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Zusammenfassung:INTRODUCTIONGrowing evidence suggests that multiple factors, such as insulin resistance, nutritional factors, gut microbiota, and hormones released from the adipose tissue, act together on genetically predisposed individuals. We aimed to investigate whether various single-nucleotide polymorphisms (SNPs) play a role in the development of nonalcoholic fatty liver disease (NAFLD) and severity of liver damage in the Anatolian population. METHODSTwo hundred and sixteen patients with biopsy-proven NAFLD and 150 control participants, aged 18–70 years, were consecutively enrolled in this multicenter study. Blood samples were genotyped for the PNPLA3 (rs738409), IL28B (rs12979860, rs12980275, rs8099917), PPAR-α 227 ALA, PPAR-γ pro 12 ALA, SOD2 C47T, and LOX-1 IVS4–14 polymorphisms using the custom-made LightSNiP assays on a LightCycler 480 II instrument. RESULTSGenotypic distributions of PNPLA3 rs738409 SNPs were different between NAFLD and control participants, but not for other SNPs. The PNPLA3 rs738409 GG polymorphism was associated with a 27-fold increased risk of development of NAFLD (odds ratio=27.8, 95% confidence interval3.5–218.4; P=0.002). Patients with the PNPLA3 GG genotype had higher nonalcoholic fatty liver disease activity score levels compared with patients with the PNPLA3 CC genotype (P
ISSN:0954-691X
1473-5687
DOI:10.1097/MEG.0000000000000813