Intramuscular Injection of Exogenous Leptin Induces Adiposity, Glucose Intolerance and Fatty Liver by Repressing the JAK2-STAT3/PI3K pathway in a Rat Model

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Veröffentlicht in:	General and comparative endocrinology 2017-10, Vol.252, p.88-96
Hauptverfasser:	Wu, Lihong, Chen, Guoxiong, Liu, Wen, Yang, Xuechao, Gao, Jie, Huang, Liwen, Guan, Hongbing, Li, Zhengmao, Zheng, Zhichao, Li, Meiling, Gu, Weiwang, Ge, Linhu
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose Tissue - metabolism Adiposity - drug effects Animals Body Weight - drug effects Disease Models, Animal Eating - drug effects Endocrinology & Metabolism Fatty liver Fatty Liver - metabolism Female Glucose intolerance Glucose Intolerance - blood Glucose Intolerance - metabolism Hyperglycemia - blood Hyperglycemia - complications Hyperglycemia - metabolism Immunity - drug effects Injections, Intramuscular Insulin - metabolism Insulin-Secreting Cells - drug effects Insulin-Secreting Cells - metabolism JAK2-STAT3 Janus Kinase 2 - metabolism Leptin Leptin - administration & dosage Leptin - adverse effects Leptin - blood Lipids - blood Liver - drug effects Liver - metabolism Obesity Phosphatidylinositol 3-Kinase - metabolism Phosphorylation - drug effects PI3K Rats, Sprague-Dawley Receptors, Leptin - metabolism Signal Transduction - drug effects STAT3 Transcription Factor - metabolism Sterol Regulatory Element Binding Protein 1 - metabolism
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