Efficacy of clade 2.3.2 H5 commercial vaccines in protecting chickens from clade 2.3.4.4 H5N8 highly pathogenic avian influenza infection

Highlights • Commercial clade 2.3.2. H5 vaccines elicit suboptimal antibody to clade 2.3.4.4 H5N8. • Three of four commercial vaccines protect vaccinated chickens from lethal infection. • All four vaccines fail to prevent shedding of the virus at early phase of infection. • The survived chickens had...

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Veröffentlicht in:	Vaccine 2017-03, Vol.35 (9), p.1316-1322
Hauptverfasser:	Yuk, Seong-su, Erdene-Ochir, T.O, Kwon, Jung-Hoon, Noh, Jin-Yong, Hong, Woo-tack, Jeong, Jei-Hyun, Jeong, Sol, Gwon, Gyeong-Bin, Shin, Jong-il, Sur, Jung-Hyang, Song, Chang-Seon
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animal diseases Animal vaccines Animals Antibodies, Viral - blood Antigens Avian flu Bird migration Chicken Chickens China - epidemiology Disease Outbreaks - prevention & control Disease Outbreaks - veterinary Epidemics Germany - epidemiology H5N8 Hemagglutination Inhibition Tests Hemagglutinin Glycoproteins, Influenza Virus - immunology Highly pathogenic avian influenza Immunization Influenza A Virus, H5N1 Subtype - immunology Influenza A Virus, H5N8 Subtype - immunology Influenza A Virus, H5N8 Subtype - pathogenicity Influenza in Birds - epidemiology Influenza in Birds - immunology Influenza in Birds - mortality Influenza in Birds - prevention & control Influenza Vaccines - administration & dosage Influenza Vaccines - adverse effects Influenza Vaccines - immunology Italy - epidemiology Migratory birds Mortality Netherlands - epidemiology Poultry Poultry Diseases - immunology Poultry Diseases - prevention & control Poultry Diseases - virology Public health Republic of Korea - epidemiology United Kingdom - epidemiology Vaccine Vaccine Potency Vaccines Virus Shedding Viruses
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Beschreibung
Zusammenfassung:	Highlights • Commercial clade 2.3.2. H5 vaccines elicit suboptimal antibody to clade 2.3.4.4 H5N8. • Three of four commercial vaccines protect vaccinated chickens from lethal infection. • All four vaccines fail to prevent shedding of the virus at early phase of infection. • The survived chickens had mild-to-severe inflammation in internal organs.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2017.01.033