Comparison of specular microscopy and ultrasound pachymetry before and after cataract surgery
Purpose To compare specular microscopy (Topcon SP-3000P, Topcon Corporation, Tokyo, Japan) and ultrasound (US) technology when evaluating central corneal thickness (CCT) prior to and after phacoemulsification. Methods Corneal edema was assessed in phacoemulsification patients due to senile cataract...
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| Veröffentlicht in: | Graefe's archive for clinical and experimental ophthalmology 2017-02, Vol.255 (2), p.387-392 |
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| creator | López-Miguel, Alberto Sanchidrián, María Fernández, Itziar Holgueras, Alfredo Maldonado, Miguel J. |
| description | Purpose
To compare specular microscopy (Topcon SP-3000P, Topcon Corporation, Tokyo, Japan) and ultrasound (US) technology when evaluating central corneal thickness (CCT) prior to and after phacoemulsification.
Methods
Corneal edema was assessed in phacoemulsification patients due to senile cataract by measuring CCT preoperatively and 1 day, 1 month, and 3 months postoperatively. Bland–Altman analysis was performed to assess interchangeability between pachymetry techniques for each visit. Repeated measures analysis of variance was performed to evaluate variation in CCT agreement depending on the degree of corneal edema.
Results
One hundred and eighteen patients aged 73.9 ± 10.1 years were recruited. Topcon SP-3000P provided significant (
p
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| doi_str_mv | 10.1007/s00417-016-3537-1 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1872835571</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>4312390151</sourcerecordid><originalsourceid>FETCH-LOGICAL-c405t-248b6783d0e312b1fc65d08f2fafe090978968a80601fcd84a3aaa7cb2e216353</originalsourceid><addsrcrecordid>eNqNkU9P3DAQxS3UCpaFD9ALitQLl5SxHf_JsVq1gITEhUpckDVx7HZREgc7OeTb42WhQkiVevJI85vnmfcI-ULhGwVQFwmgoqoEKksuuCrpAVnRiotSAbv_RFagGC01Z_dH5DilR8g4F_SQHDGlla5YvSIPm9CPGLcpDEXwRRqdnTuMRb-1MSQbxqXAoS3mboqYwpzLEe2fpXdTXIrG-RDdC4B-crGwOGFEOxVpjr9dXE7IZ49dcqev75r8-vnjbnNV3txeXm--35S2AjGVrNKNVJq34DhlDfVWiha0Zx69gxpqpWupUYOE3Gt1hRwRlW2YY1Tm09fkfK87xvA0uzSZfpus6zocXJiToVoxzYVQ9D_QiteMKiYz-vUD-hjmOORDMiUFE7LOhq4J3VM7w1J03oxx22NcDAWzi8nsYzI5JrOLyeyWOHtVnpvetX8n3nLJANsDKbeGbOW7r_-p-gyyxp1B</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1865256904</pqid></control><display><type>article</type><title>Comparison of specular microscopy and ultrasound pachymetry before and after cataract surgery</title><source>MEDLINE</source><source>SpringerLink (Online service)</source><creator>López-Miguel, Alberto ; Sanchidrián, María ; Fernández, Itziar ; Holgueras, Alfredo ; Maldonado, Miguel J.</creator><creatorcontrib>López-Miguel, Alberto ; Sanchidrián, María ; Fernández, Itziar ; Holgueras, Alfredo ; Maldonado, Miguel J.</creatorcontrib><description>Purpose
To compare specular microscopy (Topcon SP-3000P, Topcon Corporation, Tokyo, Japan) and ultrasound (US) technology when evaluating central corneal thickness (CCT) prior to and after phacoemulsification.
Methods
Corneal edema was assessed in phacoemulsification patients due to senile cataract by measuring CCT preoperatively and 1 day, 1 month, and 3 months postoperatively. Bland–Altman analysis was performed to assess interchangeability between pachymetry techniques for each visit. Repeated measures analysis of variance was performed to evaluate variation in CCT agreement depending on the degree of corneal edema.
Results
One hundred and eighteen patients aged 73.9 ± 10.1 years were recruited. Topcon SP-3000P provided significant (
p
< 0.0001) lower CCT values than US with and without induced corneal edema. Mean differences between CCT techniques for baseline, 1 day, 1 month and 3 months after cataract surgery were −28.9 ± 22.6, −30.5 ± 41.4, −32.3 ± 16.2 and −33.0 ± 16.9 μm, respectively. The systematic bias observed was not significantly different among the 4 visits (p = 0.59). The estimated limits of agreement (based on 1.96 standard deviation) were substantial, being 90.5, 165.8, 64.9 and 67.5 um at baseline, 1 day and 1 and 3 months.
Conclusions
Topcon SP-3000P provides similar systematic bias in comparison with US technique for CCT measurements regardless of the degree of corneal edema after phacoemulsification, which should be reduced after applying a constant calibration adjustment of ∼30 μm. However, interchangeability between techniques may be still limited by the notable random measurement error.</description><identifier>ISSN: 0721-832X</identifier><identifier>EISSN: 1435-702X</identifier><identifier>DOI: 10.1007/s00417-016-3537-1</identifier><identifier>PMID: 27878429</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Aged ; Aged, 80 and over ; Cornea ; Cornea - diagnostic imaging ; Corneal Edema - diagnosis ; Corneal Pachymetry - methods ; Female ; Follow-Up Studies ; Humans ; Male ; Medicine ; Medicine & Public Health ; Microscopy - methods ; Middle Aged ; Ophthalmology ; Phacoemulsification - adverse effects ; Postoperative Complications ; Postoperative Period ; Preoperative Period ; Reproducibility of Results ; Time Factors</subject><ispartof>Graefe's archive for clinical and experimental ophthalmology, 2017-02, Vol.255 (2), p.387-392</ispartof><rights>Springer-Verlag Berlin Heidelberg 2016</rights><rights>Graefe's Archive for Clinical and Experimental Ophthalmology is a copyright of Springer, 2017.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c405t-248b6783d0e312b1fc65d08f2fafe090978968a80601fcd84a3aaa7cb2e216353</citedby><cites>FETCH-LOGICAL-c405t-248b6783d0e312b1fc65d08f2fafe090978968a80601fcd84a3aaa7cb2e216353</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00417-016-3537-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00417-016-3537-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27878429$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>López-Miguel, Alberto</creatorcontrib><creatorcontrib>Sanchidrián, María</creatorcontrib><creatorcontrib>Fernández, Itziar</creatorcontrib><creatorcontrib>Holgueras, Alfredo</creatorcontrib><creatorcontrib>Maldonado, Miguel J.</creatorcontrib><title>Comparison of specular microscopy and ultrasound pachymetry before and after cataract surgery</title><title>Graefe's archive for clinical and experimental ophthalmology</title><addtitle>Graefes Arch Clin Exp Ophthalmol</addtitle><addtitle>Graefes Arch Clin Exp Ophthalmol</addtitle><description>Purpose
To compare specular microscopy (Topcon SP-3000P, Topcon Corporation, Tokyo, Japan) and ultrasound (US) technology when evaluating central corneal thickness (CCT) prior to and after phacoemulsification.
Methods
Corneal edema was assessed in phacoemulsification patients due to senile cataract by measuring CCT preoperatively and 1 day, 1 month, and 3 months postoperatively. Bland–Altman analysis was performed to assess interchangeability between pachymetry techniques for each visit. Repeated measures analysis of variance was performed to evaluate variation in CCT agreement depending on the degree of corneal edema.
Results
One hundred and eighteen patients aged 73.9 ± 10.1 years were recruited. Topcon SP-3000P provided significant (
p
< 0.0001) lower CCT values than US with and without induced corneal edema. Mean differences between CCT techniques for baseline, 1 day, 1 month and 3 months after cataract surgery were −28.9 ± 22.6, −30.5 ± 41.4, −32.3 ± 16.2 and −33.0 ± 16.9 μm, respectively. The systematic bias observed was not significantly different among the 4 visits (p = 0.59). The estimated limits of agreement (based on 1.96 standard deviation) were substantial, being 90.5, 165.8, 64.9 and 67.5 um at baseline, 1 day and 1 and 3 months.
Conclusions
Topcon SP-3000P provides similar systematic bias in comparison with US technique for CCT measurements regardless of the degree of corneal edema after phacoemulsification, which should be reduced after applying a constant calibration adjustment of ∼30 μm. However, interchangeability between techniques may be still limited by the notable random measurement error.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Cornea</subject><subject>Cornea - diagnostic imaging</subject><subject>Corneal Edema - diagnosis</subject><subject>Corneal Pachymetry - methods</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Microscopy - methods</subject><subject>Middle Aged</subject><subject>Ophthalmology</subject><subject>Phacoemulsification - adverse effects</subject><subject>Postoperative Complications</subject><subject>Postoperative Period</subject><subject>Preoperative Period</subject><subject>Reproducibility of Results</subject><subject>Time Factors</subject><issn>0721-832X</issn><issn>1435-702X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqNkU9P3DAQxS3UCpaFD9ALitQLl5SxHf_JsVq1gITEhUpckDVx7HZREgc7OeTb42WhQkiVevJI85vnmfcI-ULhGwVQFwmgoqoEKksuuCrpAVnRiotSAbv_RFagGC01Z_dH5DilR8g4F_SQHDGlla5YvSIPm9CPGLcpDEXwRRqdnTuMRb-1MSQbxqXAoS3mboqYwpzLEe2fpXdTXIrG-RDdC4B-crGwOGFEOxVpjr9dXE7IZ49dcqev75r8-vnjbnNV3txeXm--35S2AjGVrNKNVJq34DhlDfVWiha0Zx69gxpqpWupUYOE3Gt1hRwRlW2YY1Tm09fkfK87xvA0uzSZfpus6zocXJiToVoxzYVQ9D_QiteMKiYz-vUD-hjmOORDMiUFE7LOhq4J3VM7w1J03oxx22NcDAWzi8nsYzI5JrOLyeyWOHtVnpvetX8n3nLJANsDKbeGbOW7r_-p-gyyxp1B</recordid><startdate>20170201</startdate><enddate>20170201</enddate><creator>López-Miguel, Alberto</creator><creator>Sanchidrián, María</creator><creator>Fernández, Itziar</creator><creator>Holgueras, Alfredo</creator><creator>Maldonado, Miguel J.</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>20170201</creationdate><title>Comparison of specular microscopy and ultrasound pachymetry before and after cataract surgery</title><author>López-Miguel, Alberto ; Sanchidrián, María ; Fernández, Itziar ; Holgueras, Alfredo ; Maldonado, Miguel J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c405t-248b6783d0e312b1fc65d08f2fafe090978968a80601fcd84a3aaa7cb2e216353</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Cornea</topic><topic>Cornea - diagnostic imaging</topic><topic>Corneal Edema - diagnosis</topic><topic>Corneal Pachymetry - methods</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Microscopy - methods</topic><topic>Middle Aged</topic><topic>Ophthalmology</topic><topic>Phacoemulsification - adverse effects</topic><topic>Postoperative Complications</topic><topic>Postoperative Period</topic><topic>Preoperative Period</topic><topic>Reproducibility of Results</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>López-Miguel, Alberto</creatorcontrib><creatorcontrib>Sanchidrián, María</creatorcontrib><creatorcontrib>Fernández, Itziar</creatorcontrib><creatorcontrib>Holgueras, Alfredo</creatorcontrib><creatorcontrib>Maldonado, Miguel J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest_Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Graefe's archive for clinical and experimental ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>López-Miguel, Alberto</au><au>Sanchidrián, María</au><au>Fernández, Itziar</au><au>Holgueras, Alfredo</au><au>Maldonado, Miguel J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of specular microscopy and ultrasound pachymetry before and after cataract surgery</atitle><jtitle>Graefe's archive for clinical and experimental ophthalmology</jtitle><stitle>Graefes Arch Clin Exp Ophthalmol</stitle><addtitle>Graefes Arch Clin Exp Ophthalmol</addtitle><date>2017-02-01</date><risdate>2017</risdate><volume>255</volume><issue>2</issue><spage>387</spage><epage>392</epage><pages>387-392</pages><issn>0721-832X</issn><eissn>1435-702X</eissn><abstract>Purpose
To compare specular microscopy (Topcon SP-3000P, Topcon Corporation, Tokyo, Japan) and ultrasound (US) technology when evaluating central corneal thickness (CCT) prior to and after phacoemulsification.
Methods
Corneal edema was assessed in phacoemulsification patients due to senile cataract by measuring CCT preoperatively and 1 day, 1 month, and 3 months postoperatively. Bland–Altman analysis was performed to assess interchangeability between pachymetry techniques for each visit. Repeated measures analysis of variance was performed to evaluate variation in CCT agreement depending on the degree of corneal edema.
Results
One hundred and eighteen patients aged 73.9 ± 10.1 years were recruited. Topcon SP-3000P provided significant (
p
< 0.0001) lower CCT values than US with and without induced corneal edema. Mean differences between CCT techniques for baseline, 1 day, 1 month and 3 months after cataract surgery were −28.9 ± 22.6, −30.5 ± 41.4, −32.3 ± 16.2 and −33.0 ± 16.9 μm, respectively. The systematic bias observed was not significantly different among the 4 visits (p = 0.59). The estimated limits of agreement (based on 1.96 standard deviation) were substantial, being 90.5, 165.8, 64.9 and 67.5 um at baseline, 1 day and 1 and 3 months.
Conclusions
Topcon SP-3000P provides similar systematic bias in comparison with US technique for CCT measurements regardless of the degree of corneal edema after phacoemulsification, which should be reduced after applying a constant calibration adjustment of ∼30 μm. However, interchangeability between techniques may be still limited by the notable random measurement error.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>27878429</pmid><doi>10.1007/s00417-016-3537-1</doi><tpages>6</tpages></addata></record> |
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| ispartof | Graefe's archive for clinical and experimental ophthalmology, 2017-02, Vol.255 (2), p.387-392 |
| issn | 0721-832X 1435-702X |
| language | eng |
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| source | MEDLINE; SpringerLink (Online service) |
| subjects | Aged Aged, 80 and over Cornea Cornea - diagnostic imaging Corneal Edema - diagnosis Corneal Pachymetry - methods Female Follow-Up Studies Humans Male Medicine Medicine & Public Health Microscopy - methods Middle Aged Ophthalmology Phacoemulsification - adverse effects Postoperative Complications Postoperative Period Preoperative Period Reproducibility of Results Time Factors |
| title | Comparison of specular microscopy and ultrasound pachymetry before and after cataract surgery |
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